QUALITY OF LIFE OF PATIENTS WITH INTESTINAL INFLAMMATORY DISEASES DURING MEDICINAL TREATMENT
Keywords:
inflammatory bowel disease, Crohn's disease, ulcerative colitis, quality of life, SF-36, medical therapy, dynamics.Abstract
Medical therapy led to a statistically significant improvement in QoL indicators across all 8 scales of the SF-36 questionnaire, as well as the physical (PCS) and mental (MCS) health components (p<0.01 for all scales). The most pronounced improvement in QoL was observed in patients receiving genetically engineered biological drugs. Baseline disease activity and type of IBD also influenced the degree of QoL improvement. Treatment of IBD leads to a significant improvement in various aspects of patients' quality of life, which can be effectively assessed using the generic SF-36 questionnaire. This questionnaire can serve as a useful tool for monitoring patients' condition and evaluating the effectiveness of therapeutic interventions in real clinical practice.
References
Rogler G, Singh A, Kavanaugh A, Rubin DT. Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management. Gastroenterology. 2021;161(4):1118-1132. doi: 10.1053/j.gastro.2021.07.042.
Abdulla M, Hallak Y, Sawaf B, et al. Impact of inflammatory bowel disease on quality of life and fatigue: a systematic review and meta-analysis. Inflamm Bowel Dis. 2025;31(1):S66.
Olivera PA, Parks ML, Zubiaurre I, Peyrin-Biroulet L, Lasa JS, Targownik LE. Comparative Improvement in Health-Related Quality of Life With Advanced Therapies for Moderate-to-Severe Crohn's Disease: A Network Meta-Analysis. Am J Gastroenterol. 2025 Jan 29. doi: 10.14309/ajg.0000000000003333.
Stroie T, Preda C, Meianu C, Croitoru A, Gheorghe L, Gheorghe C, Diculescu M. Health-Related Quality of Life in Patients with Inflammatory Bowel Disease in Clinical Remission: What Should We Look For? Medicina (Kaunas). 2022;27;58(4):486.
Knowles SR, Graff LA, Wilding H, et al. Quality of Life in Inflammatory Bowel Disease: A Systematic Review and Meta-analyses-Part II. Inflamm Bowel Dis. 2018 Apr 23;24(5):966-976. doi: 10.1093/ibd/izy015.
Farinelli E. [et al.]. Predictors of Disease Severity in Inflammatory Bowel Disease. American Journal of Gastroenterology 2018;113():p S10-S11.
Zhang Y, Zhang L, Gao X, et al. Impact of malnutrition and sarcopenia on quality of life in patients with inflammatory bowel disease: A multicentre study. J Cachexia Sarcopenia Muscle. 2023 Dec;14(6):2663-2675. doi: 10.1002/jcsm.13341.
Хавкин АИ, Николайчук КМ, Николаева ВД. [и др.] Оценка качества жизни пациентов с воспалительными заболеваниями кишечника в зависимости от проводимой лекарственной терапии. Экспериментальная и клиническая гастроэнтерология. 2024;(8):258-272
Князев О.В., Каграманова А.В., Болдырева О.Н., и др. Антицитокиновая терапия и качество жизни больных воспалительными заболеваниями кишечника. Доказательная гастроэнтерология. 2014;3(2):28-36.
Бандель В.Е., Михайлова Е.И., Трофимова Н.В. Качество жизни и психоэмоциональные нарушения как критерий эффективности терапии у пациентов с язвенным колитом. Гепатология и гастроэнтерология. 2022;6(1):77–81.
