FUNCTIONAL MORPHOLOGY OF THE BLOOD-BRAIN AND LIQUOR-ENCEPHALIC BARRIERS OF THE BRAIN UNDER PHYSIOLOGICAL CONDITIONS

Authors

  • Indiaminov S.I.
  • Khamraev A.Kh.

Keywords:

brain, barriers, blood-brain barrier, cerebrospinal barrier, functional morphology under physiological conditions, further research, medical and social significance.

Abstract

The article summarizes data from contemporary scientific literature devoted to the functional morphology of the biological barriers of the brain. It provides a detailed description of the structural components and functional roles of the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCSFB), which play a crucial role in maintaining homeostasis. It is noted that further studies of the functional organization of biological barriers in experimental animals under physiological conditions and during various intoxications—particularly intoxications caused by pesticides widely used in agriculture—will help identify the pathophysiological and pathomorphological mechanisms underlying damage to the structures of the BBB and BCSFB.

References

Abbott N. J., Patabendige A. A., Dolman D. E., Yusof S. R., Begley D. J. Structure and function of the blood–brain barrier // Neurobiology of Disease. – 2010. – Т. 37. – № 1. – С. 13–25.

Bicker J. et al. Blood–brain barrier models and relevance for drug delivery // European Journal of Pharmaceutics and Biopharmaceutics. – 2014. – Т. 87. – № 3. – С. 409–432.

Czupalla C. J., Liebner S. Tight junctions of the blood–brain barrier // Cell and Tissue Research. – 2014.

Daneman R., Prat A. The blood–brain barrier // Neuron. – 2015.

Haseloff R. F. et al. Molecular aspects of BBB permeability // Pharmacology & Therapeutics. – 2015.

Hellström M. et al. Pericytes regulate the blood–brain barrier formation // Nature. – 2001.

Jin Y. et al. Glycocalyx degradation and BBB leakage // Brain Research. – 2021.

Johanson C. E. Blood–cerebrospinal fluid barrier physiology // Fluids and Barriers of the CNS. – 2018.

Kugler P. et al. CSF–brain barrier transport mechanisms // Brain Research Reviews. – 2021.

Lier J. et al. Cerebrovascular and BBB alterations // Acta Neuropathologica. – 2020.

Liu X. et al. Liquor–brain barrier structure and functions // Frontiers in Cellular Neuroscience. – 2020.

Menezes M. J. et al. Basement membrane structure in CNS microvessels // Developmental Biology. – 2014.

Nag S., Begley D. J. Blood–brain barrier transport studies // Neurochemical Research. – 2005.

Pardridge W. M. Drug transport from CSF to brain // Fluids and Barriers of the CNS. – 2016.

Ronaldson P. T., Davis T. P. Regulation of the BBB by inflammatory pathways // Frontiers in Neuroscience. – 2020.

Rutkowsky J. M. et al. Structural changes of the BBB in disease // Journal of Cerebral Blood Flow & Metabolism. – 2018.

Santa-Maria A. et al. Glycocalyx and BBB integrity // Journal of Cerebral Blood Flow & Metabolism. – 2021.

Seetha Harilal S. et al. Blood–brain barrier research overview // [Journal name not indicated]. – 2023.

Stolp H. B., Dziegielewska K. M. et al. Breakdown of the blood–brain barrier to proteins in white matter of the developing brain // Neuropathology and Applied Neurobiology. – 2011.

Sweeney M. D., Ayyadurai S., Zlokovic B. V. Blood–brain barrier: From physiology to disease and back // Physiological Reviews. – 2018.

Wang H. et al. Blood–brain barrier dysfunction // Frontiers in Neuroscience. – 2019.

Wardlaw J. M. et al. Perivascular spaces in brain disease // Nature Reviews Neurology. – 2020.

Published

2026-04-13