MORPHOLOGICAL CHANGES IN THE PERIPHERAL LYMPH NODES OF 12-MONTH-OLD OUTBRED WHITE RATS WITH EXPERIMENTAL RHEUMATOID ARTHRITIS
Keywords:
experimental arthritis model, peripheral lymphoid tissue, quantitative morphometry, follicular lymphoid architecture, germinal center activity, stromal microenvironmentAbstract
The study examined morphological and morphometric changes in peripheral lymph nodes of 12-month-old outbred white rats with experimental rheumatoid arthritis. The total lymph node diameter, thickness of cortical and paracortical zones, number and size of lymphoid follicles, proportion of germinal centers, as well as medullary and stromal parameters were determined and statistically analyzed. The study demonstrates that experimental rheumatoid arthritis leads to pronounced structural alterations in lymph nodes, reflected by modifications in the relative distribution of lymphoid and stromal compartments.
References
Ayer, L. M., Issekutz, A. C., Waterhouse, et all. 2000 //Cytokine mRNA in the joints and draining lymph nodes of rats with adjuvant arthritis and effects of cyclosporin A. Inflammation// 24, 447–461.
Giyosova, S. N and Radjabov, A. B. 2026 //Morphometric analysis of prostate gland tissue in rats with experimentally induced rheumatoid arthritis//
Histopathological appraisals in the lymph node and spleen of induced arthritis rat model treated with ginger and curcuma.2021//Assiut University Journal of Multidisciplinary Scientific Research// 50(2), 98–128.
Induced lymphatic circulation decreases IL 17 expression in the lymph nodes of rats in adjuvant induced arthritis 2020 // The Journal of Immunology, 204(1_Supplement), 142.30.
Pearson, C. M. 2009 // Reevaluation of inguinal lymph node injection for production of adjuvant arthritis in the rat // International Archives of Allergy and Applied Immunology// 51(3), 359–367.
Ревматоидный артрит: лабораторные модели заболевания. 2025//Rusmed.
Inoyatullaev, M. 2022 // Внесуставные проявления ревматоидного артрита// Yevrosiyo tibbiyot va tabiiy fanlar jurnali, 2(13), 314–321.
Revmatoid artritda Fetuin-A ning klinik va prognostik ahamiyati2025// Tashkent Medical Academy Repository.
Zamma, T.1983//Adjuvant induced arthritis in the temporomandibular joint of rats//Infection and Immunity, 39(3), 1291–1299.
Goryacheva, D. V. 2018// Dysregulation of immune mechanisms as a basic cause of rheumatoid arthritis // Meditsina (Almaty, Kazakhstan), 3, 32–42.
Mashmudova, G. F. 2024 // Morphological changes of the spleen in experimental rheumatoid arthritis induced by Freund’s adjuvant//Vestnik Fundament. i Klinicheskoi Meditsiny, 12(6), 163–167.
Histopathological appraisals in the lymph node and spleen of induced arthritis rat model treated with ginger and curcuma.2021//Assiut University Journal of Multidisciplinary Scientific Research// 50(2), 98–128.
