DYNAMICS OF TIREOID, AUTOIMMUNE, AND MICRONUTRIENT MARKERS IN PATIENTS WITH TIREOID PATHOLOGY UNDER A 12-MONTH PREVENTION PROGRAM
Keywords:
thyroid gland, hypothyroidism, iodine deficiency, AT-TPO, prevention, hormones, ultrasound, endocrinology, autoimmune thyroiditis, thyroid status.Abstract
In recent years, thyroid diseases have been steadily increasing, making them one of the most significant medical and social problems. This study is aimed at assessing the prevalence of thyroid disorders, risk factors, hormonal and immunological features, and the effectiveness of comprehensive preventive measures within the framework of the National Strategy for Endocrinological Health. The study included 150 patients aged 18-60 with various forms of thyroid pathology and 40 healthy individuals as controls. Assessment of iodine supply, hormonal profile (TTG, TT4, TT3), antibody levels (AT-TPO, AT-TG), micronutrient status, and ultrasound characteristics of the thyroid gland was conducted. Analysis showed that 42% of patients had subclinical disorders, 38% had autoimmune manifestations, and the urine iodine median in 57% of those examined did not reach optimal levels. The implemented preventive program, including iodine correction, a selenium-vitamin complex, and educational measures, led to a decrease in TSH levels by an average of 21%, hypothyroidism frequency by 28%, and ATP-TPO titers by 34% after 12 months. The obtained data confirm the need for comprehensive measures to reduce the prevalence of thyroid pathology and increase the effectiveness of national prevention programs.
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