TIZIMLI VENA ICHIGA TROMBOLITIK TERAPIYADAN KEYIN ISHEMIK INSULTDA REPERFUZIYA SINDROMINING IMMUN MEXANIZMLARI
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ishemik insult, trombolitik terapiya, alteplaza, reperfuziya sindromi##article.abstract##
Tadqiqotning maqsadi: ishemik insultga chalingan bemorlarda tizimli vena ichiga trombolitik terapiyadan so'ng reperfuziya sindromining immunopatogenetik xususiyatlarini o'rganish edi.
Materiallar va usullar. Tadqiqotga ishemik insultga chalingan 68 bemor kiritilgan. Tizimli vena ichiga trombolitik terapiyadan so'ng bemorlar reperfuziya sindromining rivojlanishiga qarab ikki guruhga bo'lingan. Birinchi guruhga reperfuziya sindromi bo'lmagan 47 bemor (69,1%), ikkinchi guruhga esa reperfuziya sindromi bo'lgan 21 bemor (30,9%) kiritilgan.
Natijalar. Tizimli vena ichiga trombolitik terapiyadan so'ng reperfuziya sindromining rivojlanishi progressiv immun-yallig'lanish nomutanosibligi bilan bog'liq bo'lib, IL-6, IL-10 va IL-10 ning ketma-ket oshishi bilan namoyon bo'ladi. Ushbu ma'lumotlar IL-6 va IL-10 ning dinamik o'sishining kombinatsiyasini noqulay reperfuziyadan keyingi kurs va rivojlanishning potentsial laboratoriya belgisi deb ёqabul qilinganda bitta o'lchovga qaraganda potentsial jihatdan katta diagnostik va prognostik qiymatga ega.
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