ANTIBIOTIKOTERAPIYA DAVRIDA NEYROSIFILISNING KLINIK-LABORATOR XUSUSIYATLARI
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neyrosifilis, miya-orqa miya suyuqligi, antibiotikoterapiya, treponema pallidum, OITS, diagnostika, penisillin, klinik shakllar##article.abstract##
Neyrosifilis - bu sifilis spiroxetasining markaziy asab tizimiga kirib borishi natijasida rivojlanadigan kasallik bo'lib, zamonaviy antibiotikoterapiya davrida ham o'zining dolzarbligini saqlab qolmoqda. So'nggi o'n yilliklarda OITS epidemiyasi va immunosupressiv holatlar tufayli neyrosifilis holatlari ko'paygan. Kasallikning klinik ko'rinishlari xilma-xil bo'lib, asimptomatik shakldan boshlab progressiv paraliz va tabeslarda kuzatiladigan og'ir neyrodegenerativ jarayonlargacha bo'lgan spektrni qamrab oladi. Zamonaviy diagnostika usullari, xususan, miya-orqa miya suyuqligining (MSS) tahlili va molekulyar-genetik tekshirish usullari neyrosifilisni erta aniqlash imkonini beradi. Antibiotikoterapiyaning keng qo'llanilishiga qaramay, ba'zi hollarda davolash samaradorligi past bo'lib, bu kasallikni o'rganishning dolzarbligini oshiradi.
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