TROMBOFILIYA GENETIK MARKERLARI AYOILLARDA TSEREBROVASKULYAR KASALLIKLAR XAVFINI PROGNOZ QILISH VA STRATIFIKATSIYA QILISH VOSITASI SIFATIDA
##article.subject##:
ishemik insult; ayollar; trombofiliya; genetika markerlari; MTHFR; F5; F2; PAI-1; prognostik qiymat.##article.abstract##
Maqsad. Ayollarda yoshga qarab stratifikatsiyani hisobga olgan holda ishemik insult rivojlanishida trombofiliya genetika markerlarining prognostik ahamiyatini baholash.
Materiallar va usullar. 24 yoshdan 74 yoshgacha bo‘lgan o‘tkir ishemik insultli 97 nafar ayol tekshirildi. Tadqiqot tarkibiga kliniko-nevrologik baholash, laborator-koagulologik tahlillar, shuningdek, MTHFR C677T, F5 G1691A, F2 G20210A va PAI-1 675 4G/5G polimorfizmlarining molekulyar-genetik testlari kiritildi. Nazorat guruhini serebrovaskulyar patologiya belgilari bo‘lmagan 30 nafar shartli sog‘lom ayollar tashkil etdi. Statistik ishlov berishda χ²-mezoni, ishonch intervallari bilan odds ratio (OR) hisoblash, ROC-tahlil (AUC, sezgirlik, spetsifiklik) qo‘llanildi. Natijalar. Yosh ayollarda trombofiliyaga xos variantlar tashuvchiligi tez-tez uchradi: MTHFR (T/T – 44 %), F2 (A/A – 42 %) va F5 (A/A – 17 %), ular D-dimer darajasining oshishi (456,11 ± 83,29 ng/ml) va tranzitor ishemik xurujlar epizodlari bilan birga kuzatildi. Qariyalar guruhida asosan tomir-metabolik omillar ustun bo‘ldi (arterial gipertenziya – 100 %, qandli diabet – 59 %, ateroskleroz – 66 %). MTHFR C677T va PAI-1 675 4G/5G polimorfizmlari ROC-tahlilda yuqori prognostik qiymat ko‘rsatdi (AUC > 0,70). Genetik va kliniko-laborator prediktorlar majmuasi ayollarda insult patogenezining yoshga xos xususiyatlarini aniqlash imkonini berdi.
Xulosalar. Trombofiliya genetika markerlari ayollarda insult xavfini baholashda muhim prognostik ahamiyatga ega bo‘lib, ayniqsa yosh guruhda ahamiyati katta. Yoshga qarab stratifikatsiya prognoz aniqligini oshiradi hamda profilaktika va terapiyada shaxsiylashtirilgan yondashuv zarurligini asoslaydi.
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