NEUROIMMUNOLOGICAL DIAGNOSIS FOR MOTOR NEURON DISEASE

Authors

  • Rakhimbayeva Gulnora Sattarovna
  • Akbarova Saida Bahtiyorovna
  • Равзатов Жасурбек Бахромович

Keywords:

Motor neuron disease, amyotrophic lateral sclerosis, myelin associated glycoprotein (MAG)

Abstract

Amyotrophic lateral sclerosis (ALS), a fatal neurological disorder also known as Lou Gehrig's disease, is a chronic, slowly progressive disease in which the leading clinical syndromes are spastic-atrophic paresis of the limbs and bulbar disorders caused by combined damage to the central and peripheral motor neurons. Currently, the etiology of sporadic ALS is not fully understood. However, 10-20% of patients have a predisposition to autoimmune processes.

References

Latov N. Antibodies t o glycoconjugates in neuropathy and motor-neuron disease. Proc Brain Res 1994;101:295–303.

Chassande B., Leger J.M., Younes- Chennoufi et al. Peripheral neuropathy associated with IgM monoclonal gammopathy: correlations between M-protein antibody activity and clinical/electrophysiological features in 40 cases. Muscle Nerve

;21:55–62.

Kornberg A.J., Pestronk A. Chronic motor neuropathies: diagnosis, therapy, and pathogenesis. Ann Neurol 1995;37 Suppl

:43–50.

Ilyas A.A., Quarles R.H., Dalakas M.C.

et al. Monoclonal IgM in patient with paraproteinemic polyneuropathy binds to gangliosides containing disialosyl groups. Ann Neurol 1985;18:655–9.

Willison H.J., O’Learly, Veitch J. et al. The clinical and laboratory features of chronic sensory ataxic neuropathy with anti-disialosyl IgM antibodies. Brain 2001;24:1968–77.

Ilyas A.A., Willison H.J., Quarles R.H.

et al. Serum antibodies to gangliosides in Guillain-Barre syndrome. Ann Neurol 1988;23:440–7.

Svennerholm L. Designation and schematic structure of gangliosides and allied glycosphingolipids. Prog Brain Res

;101:11–4.

Weller M., Stevens A., Sommer N. et al. Ganglioside antibodies: a lack of diagnostic specificity and clinical utility? J Neurol

;239:455–59.

Yuki N., Yoshino H., Sato S., Miyatake T. Acute axonal polyneuropathy associated with anti-GM1 antibodies following Campylobacter enteritis. Neurology 1990;40:1900–2.

Chiba A., Kusunoki S., Obata H. et al. Serum anti-GQ1b IgG antibody is associated with ophthalmoplegia in Miller Fisher syndrome and Guillain-Barre syndrome: clinical and immunohistochemical studies. Neurology 1993;43:1911–7.

Gong Y., Lunn M.P., Heffer-Lauc M. et al. Localization of major gangliosides in the PNS: implications for immune neuropathies.

J Periph Nerv Syst 2001;6:42.

Corbo M., Quattrini A., Latov N., Hays A.P. Localisation of GM1 and Gal(beta1-3)GalNAc antigenic determinants in peripheral nerve. Neurology 1993;43:809–14.

O’Hanlon G.M., Paterson G.J., Veitch J. et al. Mapping immunoreactive epitopes in the the human peripheral nervous system using human monoclonal anti-GM1 ganglioside antibodies. Acta Neuropathol (Berl)

;95:605–16.

Zielasek J., Ritter G., Magi S. et al. A comparative trial of anti-glyoconjugate antibody assays: IgM antibodies to GM1. J Neurol 1994;241:475–80.

Willison H., Yuki N. Peripheral neuropathies and anti-glycolipid antibodies. Brain 2002;125:2591–625.

Published

2024-01-05