SURUNKALI NEVROPATIK OG‘RIQ SINDROMI SHAKLLANISHIDAGI MOLEKULYAR-NEYROFIZIOLOGIK O‘ZARO TA’SIRLAR: KLINIK VA DIAGNOSTIK YONDASHUVLAR (ADABIYOTLAR TAHLILI)
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nevropatik og‘riq, surunkali og‘riq, biomarkerlar, sitokinlar, neyrofiziologiya, chaqirilgan potensiallar, neyroyallig‘lanish, miqdoriy sezgi testlash##article.abstract##
Surunkali nevropatik og‘riq sindromi zamonaviy tibbiyotning eng murakkab va ijtimoiy ahamiyatga ega muammolaridan biri hisoblanadi. U rivojlangan mamlakatlar katta yoshli aholisining 6,9% dan 10% gacha qismini qamrab oladi. Nevropatik og‘riqning patofiziologiyasi periferik va markaziy sezgirlik, neyroimmun o‘zaro ta’sirlar, shuningdek, pastga yo‘nalgan modullovchi tizimlarning buzilishini o‘z ichiga olgan murakkab ko‘p bosqichli jarayonlar bilan tavsiflanadi.
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Вклад авторов
Хайдарова Дилдора Кодировна внес основной вклад в разработку концепции исследования, сбор и анализ клинических данных, статистическую обработку результатов и подготовку рукописи. Сафарова Махлиё Шавкат кизи участвовала в планировании исследования, интерпретации результатов, критическом анализе и редактировании текста статьи. Оба автора принимали активное участие в обследовании и лечении пациентов, согласились принять ответственность за все аспекты работы и одобрили окончательную версию публикации.
Mualliflar hissasi
Хaydarova Dildora Qodirovna tadqiqot konsepsiyasini ishlab chiqish, klinik ma'lumotlarni yig'ish va tahlil qilish, natijalarni statistik qayta ishlash va qo'lyozmani tayyorlashda asosiy hissa qo'shdi. Safarova Maxliyo Shavkat qizi tadqiqotni rejalashtirish, natijalarni talqin qilish, tanqidiy tahlil va maqola matnini tahrirlashda ishtirok etdi. Ikkala muallif ham bemorlarni tekshirish va davolashda faol qatnashdi, ishning barcha jihatlari uchun javobgarlikni o'z zimmasiga olishga rozi bo'ldi va nashrning yakuniy nusxasini ma'qulladi.
AUTHORS CONTRIBUTIONS
Khaidarova Dildora Kodirovna made the primary contribution to the development of the research concept, collection and analysis of clinical data, statistical processing of results, and manuscript preparation. Safarova Maxliyo Shavkat qizi participated in research planning, results interpretation, critical analysis, and text editing of the article. Both authors actively participated in patient examination and treatment, agreed to take responsibility for all aspects of the work, and approved the final version of the publication.
