OPTIMIZATION OF NEUROPROTECTIVE THERAPY FOR ISCHEMIC STROKE IN THE ACUTE PERIOD
Keywords:
stroke, ischemic stroke, cerebral infarction, acute cerebrovascular accident, metabolic therapy, neuroprotective therapy, neuroprotective agents, antihypoxantsAbstract
The article demonstrates the world experience of neoroprotective therapy in the treatment of ischemic stroke in the acute perod. The feasibility of prescribing metabolic drugs is not completely clear, the effectiveness has not been definitively proven, despite numerous studies that show only trends. The drug does not reliably improve the neurological status of patients after a stroke, but it reduces the ten-year risk of stroke. Thus, the mechanisms of action of drugs and data from experimental and clinical studies, including those after neoroprotective therapy and with the inclusion of drugs for primary and secondary prevention of ischemic stroke, have been analyzed.
References
Adams, Н. Guidelines for the early Management of patients with ischemic stroke. A scientific statement from the stroke council of the American Heart Association / H.Adams, R.Adams, G.Del Zoppo et al. // Stroke. 2005. -Vol.36.-P.916-923.
Barber, P.A. The use of PWI and DWI measures in the design of "proof-concept" stroke trials / P.A.Barber, M.W.Parsons, P.M.Desmond et al. // J. Neuroimag. 2004. - Vol. 14. - P. 123—132.
Castillo, J. Progression of ischaemic stroke and exitotoxic amino acids / J.Castillo, A.Davalos, M.Noya // Lancet. 1997. - Vol.349. - P.79—83.
Chazova I.E., Oshchepkova E.V. Fight against cardiovascular diseases: problems and solutions at the present stage // Bulletin. 2015. №. 5. P. 7-10.
Fayzulin E.R. Rehabilitation of patients with cerebral ischemic stroke in the late recovery period at the outpatient stage. Irkutsk, 2009.
Fisher, M. An overview of acute stroke therapy: past, present and future / M. Fisher, W.Schaebitz // Arch. Intern. Med. 2000. - Vol.160. -P.3196—3206.
Gusev E.I., Skvortsova V.I., Stakhovskaya T.V. Epidemiology of Stroke // Journal of Neurology and Psychiatry. S.S. Korsakov. Application "Stroke". 2003. №. 8. P. 4-9.
Hippisley-Cox J., Coupland C., Brindle P. Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study // BMJ. 2017. Vol. 357. ID j2099.
Lee W., Hwang S.H., Choi H. et al. The association between smoking or passive smoking and cardiovascular diseases using a Bayesian hierarchical model: based on the 2008–2013 Korea Community Health Survey // Epidemiol. Health. 2017. Vol. 39. ID e2017026.
Parfenov V.A. Acute period of ischemic stroke: diagnosis and treatment // Neurology, neuropsychiatry, psychosomatics. 2009. №. 1. P. 5–12.
Parfenov V.A. Prevention of recurrent ischemic stroke // Russian medical journal. 2008. Vol. 16. №.12, Р. 1694-1699.
Zakharov Treatment of ischemic stroke // Russian medical journal. 2006. Vol. 14. №. 4, Р. 242–246.
Zhitkova Yu.V., Saykhunov M.V., Khasanova D.R. Prevention of cerebral circulation disorders // Consilium Medicum. 2013. T. №. 9. P. 5-8