NEUROPHYSIOLOGICAL AND BIOMARKER ASPECTS OF SPEECH FUNCTION RECOVERY IN PATIENTS WITH POST- STROKE APHASIA
Keywords:
post-stroke aphasia, neuroplasticity, speech rehabilitation, BDNF, neuromarkers, EEG, fMRI, transcranial magnetic stimulationAbstract
Post-stroke aphasia is one of the most disabling consequences of acute cerebrovascular accidents, significantly reducing patients' quality of life and limiting their social adaptation. According to the World Health Organization, aphasia develops in 21–38% of stroke survivors, while complete recovery of speech function is observed in only 40% of these cases. Modern neurophysiological methods (EEG, transcranial magnetic stimulation, functional MRI) and the identification of specific biomarkers (BDNF, S100B, NSE, GFAP) offer new opportunities for objectively assessing the dynamics of speech recovery and for personalizing rehabilitation programs.
References
Министерство здравоохранения Республики Узбекистан. Национальный клинический протокол по ведению пациентов с инсультом.— Ташкент, 2024.
ДТ Ходжиева, НК Хайдаров, ДК Хайдарова Коррекция астеноневротического синдрома энергокорректором цитофлавином. Неврология – №3. 2013.С16-19.
DT Hodzhieva, SS Pulatov, DK Hajdarova Vse o gemorragicheskom insulte lic pozhilogo i starcheskogo vozrasta.[All about hemorrhagic stroke of elderly and elderly people] Nauka molodyh-Young Science. 2015. 87-96.
Khaydarova Dildora Kadirovna, Samadov Alibek Uktamovich. Current issues in the development of neuroprotective therapy in ischemic stroke. International Scientific Research Journal (WoS) 2021.
Berthier M.L., Pulvermüller F. Neuroscience insights improve neurorehabilitation of poststroke aphasia // Nature Reviews Neurology. — 2024.— Vol. 20, № 4. — P. 215–230.
Dildora Khaydarova, Alibek Samadov. Optimization of neuroprotective therapy for ischemic stroke in the acute period. Журнал неврологии и нейрохирургических исследований. 2021.10.17.
Dildora Khaydarova, Alibek Samadov. Optimization of neuroprotective therapy for ischemic stroke in the acute period. Журнал неврологии и нейрохирургических исследований. 2021.
World Health Organization. Global Stroke Factsheet 2024. — Geneva: WHO Press, 2024. — 48 p.
Khaydarova Dildora Kadirovna, Xaydarov Nodirjon Kadirovich, Khodjyeva Dilbar Tadjiyevna. Clinical basis for the development of neuroprotective therapy in acute ischemic stroke. International Journal of Health Sciences. 2022. Р 4177-4183
Crinion J.T., Leff A.P. Recovery and treatment of aphasia after stroke: functional imaging studies // Current Opinion in Neurology. — 2024.— Vol. 37, № 6. — P. 567–578.
Dildora K Khaydarova. Сlinical implications of epidemiological and risk factor models for stroke in CKD. Central Asian Journal of Medicine. 2026/1/28. Р-154-156
DK Khaydarova, HZ Davronova. Cognitive deficit in stage ii cerebrovascular accident in patients with Рarkinson's syndrome. Global research and academic innovations. 2026/3/6. Р.201-204.
Sebastian R., Tsapkini K. Transcranial direct current stimulation in post-stroke aphasia rehabilitation: systematic review // Stroke. — 2024. — Vol. 55, № 8. — P. 2156–2168.
Kiran S., Thompson C.K. Neuroplasticity associated with aphasia treatments: clinical implications // Journal of Speech, Language, and Hearing Research. — 2024. — Vol. 67, № 5. — P. 1487–1502.
Ali M., VandenBerg K., Williams L.J. et al. Predictors of poststroke aphasia recovery: a systematic review-informed individual participant data meta-analysis // Stroke. — 2025. — Vol. 56, № 1. — P. 124–138.
