CLINICAL, NEUROPHYSIOLOGICAL, AND NEUROGLIAL FEATURES OF POST-STROKE SEIZURE SYNDROME BASED ON S100B BIOMARKER ANALYSIS
Keywords:
stroke, post-stroke seizure syndrome, ischemic stroke, hemorrhagic stroke, stroke severity, epileptic seizures, functional outcomeAbstract
This study is focused on the analysis of clinical, neurophysiological, and neuroglial features of post-stroke seizure syndrome. Laboratory parameters, EEG, and MRI findings were evaluated in relation to the S100B biomarker. The results revealed a strong association between stroke severity, neuroglial activity, and epileptogenesis. S100B was shown to be a valuable prognostic marker for improving individualized treatment strategies.
References
Bentes C, Martins H, Peralta AR, Morgado C, Casimiro C, Franco AC, et al. Early EEG predicts poststroke epilepsy. Epilepsia Open. 2018;3(2):203–212.
Khaydarova Dildora Kadirovna, Khodjyeva Dilbar Tadjiyevna, Bobokulov Gulmurod Dilmurodovich. Optimization Of Neuroprotective Therapy Of Ischemic Stroke In The Acute Period. European Journal of Molecular & Clinical Medicine. Volume 07, Issue 03, 2020. Р. 3720-3723
Khaydarova Dildora Kadirovna, Samadov Alibek Uktamovich. Current issues in the development of neuroprotective therapy in ischemic stroke. Web of Scientist: International Scientific Research Journal 2021. P. 6-10
ДТ Ходжиева, НК Хайдаров, ДК Хайдарова Коррекция астеноневротического синдрома энергокорректором цитофлавином. Неврология.–№3. 2013.С16-19.
Beretta S, Carone D, Zanchi C, Bianchi E, Pirovano M, Trentini C, et al. Long‐term applicability of the new ILAE definition
of epilepsy. Results from the PRO‐LONG study. Epilepsia. 2017;58(9):1518–1523.
Boespflug EL, Simon MJ, Leonard E, Grafe M, Woltjer R, Silbert LC, et al. Targeted assessment of enlargement of the perivascular space in Alzheimer's disease and vascular dementia subtypes implicates Astroglial involvement specific to Alzheimer's disease. J Alzheimers Dis. 2018;66(4):1587–1597.
Duncan D, Barisano G, Cabeen R, Sepehrband F, Garner R, Braimah A, et al. Analytic tools for post‐traumatic Epileptogenesis biomarker search in multimodal dataset of an animal model and human patients. Front Neuroinform. 2018;12:86.
Khaydarova Dildora Kadirovna, Xaydarov Nodirjon Kadirovich, Khodjyeva Dilbar Tadjiyevna. Clinical basis for the development of neuroprotective therapy in acute ischemic stroke. International Journal of Health Sciences. 2022.P. 4177-4183.
Hou Y, Park SH, Wang Q, Zhang J, Zong X, Lin W, et al. Enhancement of perivascular spaces in 7 T MR image using Haar
transform of non‐local cubes and block‐matching filtering. Sci Rep. 2017;7(1):8569.
Huang X, Hussain B, Chang J. Peripheral inflammation and blood‐brain barrier disruption: effects and mechanisms. CNS
Neurosci Ther. 2021;27(1):36–47.
Pande SD, Lwin MT, Kyaw KM, Khine AA, Thant AA, Win MM, et al. Post-stroke seizure - Do the locations, types and managements of stroke matter? Epilepsia Open. (2018) 3:392–8.
Ringstad G, Valnes LM, Dale AM, Pripp AH, Vatnehol SS, Emblem KE, et al. Brain‐wide glymphatic enhancement and clearance in humans assessed with MRI. JCI Insight. 2018;3(13):e121537.
Khaydarova Dildora Kadirovna, Xaydarov Nodirjon Kadirovich, Khodjyeva Dilbar Tadjiyevna. Clinical basis for the development of neuroprotective therapy in acute ischemic stroke. International Journal of Health Sciences. 2022.P. 4177-4183.
Zhao Y, Li X, Zhang K et al. The Progress of Epilepsy after Stroke. Curr Neuropharmacol 2018; 16 (1): 71–8.
