POSTINSULT REABILITATSIYASI DAVRIDA NEYROPLASTIKLIKNI MODULYATSIYA QILISHDA TRANSKUTAN STIMULYATSIYASINING ROLI (ADABIYOTLAR SHARHI)
##article.subject##:
qon tomirining bulayuvchi nervining transkutan stimulyatsiyasi, neyroplastiklik, postinsult reabilitatsiya, harakat buzulishlari, kognitiv buzulishlar, kolinergik tizim, neyromodulyatsiya##article.abstract##
Maqsad: Postinsult reabilitatsiyasi davrida neyroplastiklikni modulyatsiya qilishda qon tomirining bulayuvchi nervining transkutan stimulyatsiyasining rolini bo'yicha zamonaviy ma'lumotlarni sistemalashtirish.
Materiallar va usullar: PubMed, Scopus, Web of Science 44 ta nashr (2015–2024) tahlil qilindi.Natijalar: tVNS neyroplastiklikni ishonchili kuchaytiradi, buning sababi kolinergik anti-yallig'li yo'nalishni faollashtirish (IL-6, TNF-α ni 40– 60% ga kamaytirish), locus coeruleus-norepinefrin tizimini rag'batlantirish (norepinefrinni 35% ga oshirish) va BDNFni modulyatsiya qilish (25– 30% ga oshirish). Randomizatsiyalangan tadqiqotlar (VNS-REHAB, n=108) tVNSni reabilitatsiya bilan birlashtirganda harakat funktsiyalarining 40% (Fugl-Meyer) va kognitiv ko'rsatkichlarning 35% (MoCA) yaxshilashini ko'rsatdi. Usul xavfsiz: noxush effektlar chastoti 5% dan oshmaydi.
Xulosa: tVNS neyroplastiklikni ko'p darajali mexanizmlar orqali kuchaytiradigan istiqbolli invaziv bo'lmagan neyromodulyatsiya usulidir. Insultdan keying harakat va kognitiv nuqsonlari bo'lgan bemorlarning kompleks reabilitatsiya dasturlariga tVNSni kiritish tavsiya etiladi, ayniqsa standart terapiyaga chidamli holatlarda.
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