SCIENTIFIC ANALYSIS OF RADIOMORPHOLOGIC CORRELATIONS BETWEEN HISTOMORPHOLOGICAL ALTERATIONS AND MODERN NEUROIMAGING DATA IN TRAUMATIC BRAIN INJURY
Keywords:
traumatic brain injury, histology, MRI, CT, hemorrhage, radiomorphologic correlationAbstract
This study investigates the correlation between histological alterations and modern neuroimaging findings (MRI and CT) in traumatic brain injury (TBI). Autopsy and imaging data of 40 patients (2023–2024) were analyzed. Histological examination revealed parenchymal hemorrhages, brain edema, neuronal dystrophy, and venous congestion. MRI/CT findings showed hematomas, mass effect, and intracranial hypertension with an overall radiomorphologic concordance of 77%. The strongest correlations were observed for hemorrhage (ρ=0.86) and edema (ρ=0.79). The results demonstrate that combined histologic and imaging analysis is crucial for accurate diagnosis, prognosis, and understanding of brain injury pathogenesis.
References
World Health Organization. Neurological disorders: public health challenges. Geneva: WHO Press, 2022.
Maas A.I.R., et al. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurology, 2021; 20(10): 799–810. DOI:10.1016/S1474-4422(21)00102-8.
Nguyen R., et al. The global burden of traumatic brain injury: review and update. Brain Injury, 2023; 37(1): 13–25.
Petraglia A.L., et al. Advanced neuroimaging in traumatic brain injury. J. Neurotrauma, 2022; 39(15–16): 1102–1114.
Gao J., et al. Relationship between microstructural brain injury and cognitive outcomes: a DTI-based study. Neuroscience Letters, 2020; 733: 135110.
Li Y., et al. Morphological correlates of axonal injury in traumatic brain lesions. Acta Neuropathologica, 2022; 144(3): 455–469.
Kondo R., et al. Histopathological basis of neuroimaging findings after traumatic brain injury. Frontiers in Neurology, 2023; 14: 112389.
Brenner E., et al. Radiologic-histopathologic correlation of brain edema in trauma.*NeuroImage: Clinical, 2021; 32: 102889.
Xiang M., et al. Linking MRI abnormalities with microscopic brain pathology. Brain Pathology, 2024; 34(2): e13055.
Zhou Z., et al. Radiomorphologic correlation in acute brain trauma: a systematic review. Frontiers in Human Neuroscience, 2024; 18: 145672.