THE ROLE OF HYPERHOMOCYSTEINEMIA IN THE PATHOGENESIS OF POST-TRAUMATIC ENCEPHALOPATHY
Keywords:
post-traumatic encephalopathy; craniocerebral trauma; hyperhomocysteinemia; cognitive impairments; biochemical markers; Mini- Mental State Examination (MMSE); Montreal Cognitive Assessment (MoCA)Abstract
Post-traumatic encephalopathy (PTE) is one of the most frequent and socially significant consequences of craniocerebral trauma, accompanied by cognitive and emotional impairments. In recent years, special attention has been paid to the study of biochemical markers that reflect the severity of the pathological process and the prognosis of recovery. The aim of the study was to determine the role of hyperhomocysteinemia in the pathogenesis of PTE and its relationship with cognitive impairments. 60 patients treated at the Tashkent Regional Specialized Somatic Hospital were examined. Men predominated in the study sample (66.6%). All patients underwent blood homocysteine levels and neuropsychological testing using the MMSE and MoCA scales. It has been established that higher levels of homocysteine are associated with more pronounced cognitive deficit. A negative correlation was found between homocysteine concentration and cognitive test results. The obtained data confirm the role of hyperhomocysteinemia as a significant biomarker of post-traumatic encephalopathy and indicate the need to determine it in a comprehensive examination of patients.
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