RESULTS OF MOLECULAR GENETIC RESEARCH POLYMORPHISM OF THE Vegf rs699947 GENE IN CANCER
Keywords:
Acute cerebrovascular accident, VEGF-a gene, strokeAbstract
In patients with Acute cerebrovascular accident, the percentage of S/S, S/A, and A/A genotypes was 12.3%, 43.4%, and 44.3%, respectively, while in patients with Acute cerebrovascular accident, these indicators were 16.0%, 48.7%, and 35.3%, respectively. The type of polymorphism rs699947 studied in the VEGF-a gene, the genotype distribution was investigated in accordance with the Hardy-Weinberg equation. In the main group, the distribution of homozygous genotypes – S/S and A/A at the empirically observed and expected theoretical levels was 0.136/0.136 and 0.411/0.405, respectively. In the control group, the frequency of these genotypes was 0.187/0.18 and 0.338/0.33, respectively.
References
Vincenti V, Cassano C, Rocchi M, et al. Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3. Circulation 1996;93:1493–5.
Greenberg DA, Jin K. Vascular endothelial growth factors (VEGFs) and stroke. Cell Mol Life Sci 2013;70:1753–61.
Ogunshola OO, Stewart WB, Mihalcik V, et al. VEGF expression correlates with angiogenesis in postnatal developing rat brain. Dev Brain Res 2000;119:139–53.
Pruissen DM, Kappelle LJ, Rosendaal FR, et al. Genetic association studies in ischemic stroke: replication failure and prospects. Cerebrovasc Dis 2009;27:290–4.
Shahbazi M., Fryer A.A., Pravica V., Brogan I.J., Ramsay H.M., Hutchinson I.V., Harden P.N. Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection. J. Am. Soc. Nephrol. 2002;13:260–264.
Smith, Wade S.; Johnston, S. Claiborne; Hemphill, III, J. Claude (2019). "Cerebrovascular Diseases". In Jameson, J. Larry; Fauci, Anthony S.; Kasper, Dennis L.; Hauser, Stephen L.; Longo, Dan L.; Loscalzo, Joseph (eds.). Harrison's Principles of Internal Medicine (20th ed.) 2. Гусев Е.И., Скворцова В.И. Ишемия головного мозга, М.: Медицина, 2001. — 328 с.
Caлoмoвa Н.К. //Ocoбeннocти тeчeния и клиникo-пaтoгeнeтичecкaя xapaктepиcтикa пepвичныx и пoвтopныx инcультoв //Central Asian Journal of Medical and Natural Science. 2021.-C. 249-253.
Caлoмoвa Н. Қ., Paxмaтoвa C.Н. Қaйтa тaкpopлaнувчи ишeмик вa гeмoppaгик инcультли бeмopлapни эpтa peaбилитaция қилишни oптимaллaштиpиш // Жуpнaл нeвpoлoгии и нeйpoxиpуpгичecкиx иccлeдoвaний. 2021й. 71-76 бeт.
Salomova N.Q. //Measures of early rehabilitation of speech disorders in patients with hemorrhagic and ischemic stroke// Europe’s Journal of Psychology.2021. Vol. 17(3).-P.185-190.
Хеннерици М.Г., Богуславски Ж., Сакко Р.Л.; перевод с английского; под общей редакцией чл.-корр. РАМ Скворцовой В.И. Инсульт: Клиническое руководство.– 2-е изд. –М.: МЕДпресс-инфо, 2008. – 224 с.: ил.
Инсульт. Руководство для врачей. Под редакцией Л.В. Стаховской, С.В. Котова. Издательство МИА, 2014. — 400 с.: ил.
Тул Дж.Ф., Гусев Е.И., Сосудистые заболевания головного мозга /перевод с анг. Под ред акад. РАМН Е.И. Гусева, проф. А.Б. Гехт. Руководство для врачей: 6 изд. – М.: ГЭОТАР-Медиа, 2007. — 608 с.
Evolving Paradigms in Neuroimaging of the Ischemic Penumbra Chelsea S. Kidwell, MD; Jeffry R. Alger, PhD; Jeffrey L. Saver, MD, Stroke.2004;35[suppl I]:2662-2665.
H.S. Markus Cerebral perfusion and stroke. J Neurol Neurosurg Psychiatry 2004;75:353–361
Liebeskind DS, Jüttler E, Shapovalov Y, Yegin A, Landen J, Jauch EC Cerebral Edema Associated With Large Hemispheric Infarction. Stroke. 2019;50(9):2619. Epub 2019 Aug 20.
Крылов В.В., Никитин А.С., Дашьян В.Г., Буров С.А., Петриков С.С., Асратян С.А. Хирургия массивного ишемического инсульта. – М.: ГЭОТАР-Медиа, 2016.
Wijdicks E., Diringer M. Middle cerebral artery territory infarction and early brain swelling: progression and effect of age on outcome. Mayo Clin. Proc 1998;.73(9): 829-836.
