OPTIMIZATION OF DIAGNOSTICS AND TARGETED THERAPY APPROACHES FOR CONTINUOUS SPIKE-WAVE ACTIVITY DURING SLEEP IN PATIENTS WITH EPILEPTIC ENCEPHALOPATHY
Keywords:
Epileptic encephalopathy (EE), Epilepsy, Continuous spike-wave during sleep (CSWS).Abstract
The article discusses modern approaches to diagnostics and targeted therapy in patients with epileptic encephalopathy presenting with continuous spike-wave activity during sleep (DEE-SWAS). Considering the complexity and heterogeneity of clinical manifestations, emphasis is placed on the necessity of a multidisciplinary diagnostic approach, including detailed electroencephalography and comprehensive clinical assessment. Novel methods of targeted therapy aimed at reducing epileptic activity and improving patients’ quality of life are also reviewed. The importance of individualized treatment tailored to the specific characteristics of each patient, as well as the need for interdisciplinary collaboration among specialists, is highlighted to achieve optimal therapeutic outcomes in DEE-SWAS. The study results may contribute to improving the diagnostics and treatment of this challenging condition.
References
Pavone, P., et al. (2018). "Deep Sleep and Epileptic Encephalopathy: Implications for Management." Seizure, 61, 39-45. doi:10.1016/j.seizure.2018.07.001
Cortese, A., et al. (2019). "Clinical Spectrum of Sleep-Related Epilepsy: Insights from EEG and Clinical Features." Epilepsy Research, 153, 45-51. doi:10.1016/j.eplepsyres.2019.05.004
López-González, M. J., et al. (2020). "Diagnostic Approaches for DEE-SWAS: A Review of EEG Patterns." Clinical Neurophysiology, 131(4), 819-826. doi:10.1016/j.clinph.2019.12.005
Mullen, S. A., et al. (2016). "The Role of Sleep in Epileptic Encephalopathies: A Focus on DEE-SWAS." Epilepsia, 57(6), 953-958. doi:10.1111/epi.13424
Kobayashi, K., et al. (2017). "Clinical Features and EEG Characteristics of DEE-SWAS." Neurology, 88(17), 1670-1678. doi:10.1212/WNL.0000000000000045
