MIGREN PATOGENEZIGA YANGICHA YONDASHUVLAR (ADABIYOTLAR TAHLILI)
##article.subject##:
migren, patogenez, neyropeptid, neyroyallig‘lanish, bosh og‘rig‘i, xuruj##article.abstract##
Migren – dunyo bo‘ylab eng ko‘p uchraydigan nevrologik kasalliklardan bo‘lib, statistik ma’lumotlarga ko‘ra mehnatga layoqatsizlikka olib keluvchi kasalliklar o‘rtasida ikkinchi o‘rinda turadi. Ushbu kasallikni ayniqsa erkaklarga nisbatan ayollarda bir necha barobar ko‘p uchrashi barchamizga ma’lum. Migren kasalligining klinik belgilari, og‘irlik darajasi va asoratlari haqida uzoq yillardan buyon ma’lum bo‘lsada, uning patogenetik sabablarini aniqlash bo‘yicha haligacha izlanishlar davom etmoqda. Hozirgi kunga qadar migren patogenezida vaskulyar nazariya, serotonin nazariyasi va gormonlar ishtiroki bo‘yicha ko‘plab tadqiqotlar o‘tkazilgan. Biroq, ushbu tadqiqotlar kasallik patogenezini to‘liq ochib bera olmadi. So‘nggi yillarda xorijiy adabiyotlarda migren patogenezida neyropeptidlar o‘rni va ularni markaziy asab tizimida neyroyallig‘lanish chaqirib, migren xurujlarini yuzaga keltirishi haqidagi fikrlar keng tarqalmoqda. Shu nuqtai nazardan biz ushbu maqolamizda migren patogenezi yuzasidan amalga oshirilgan tadqiqotlarni quyida tahlil qilib chiqamiz.
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