DISTINCTIVE FEATURES OF CLINICAL AND SEMIOLOGICAL PARAMETERS IN PATIENTS WITH MESIAL TEMPORAL LOBE EPILEPSY WITH HIPPOCAMPAL SCLEROSIS
Keywords:
MTLE-HS, aura,oral automatism, neuropsychologic examination,epigastral aura,initial precipitating eventAbstract
The study involved 88 participants: the main group consisted of 30 patients diagnosed with MTLE-HS, the comparison group included 36 patients with other types of epilepsy, and the control group comprised 22 healthy individuals. A comparative analysis of clinical signs in patients revealed the following characteristics specific to MTLE-HS: presence of IPE in the medical history, relatively early age of first seizure onset, seizures accompanied by aura and autonomic symptoms, with automatisms predominating over motor movements, ictal speech arrest, versive movements, and unilateral dystonia. These were identified as diagnostically significant signs in determining the lateralization of the seizure focus. Patients with MTLE-HS demonstrated lower MoCA scores compared to the comparison group and exhibited higher levels of anxiety on the HADS scale.
References
Lewis D.V. yet al. Hippocampal sclerosis after febrile status epilepticus: The FEBSTAT study // Annals of Neurology. 2014. Vol. 75, № 2. P. 178–185.
Busch R.M. yet al. Yeffect of apolipoprotein ε4 allele on hippocampal and brain volume in intractable temporal lobe epilepsy // Epilepsy & Behavior. 2011. Vol. 21, № 1. P. 88–90.
Kasperavičiūtė D. yet al. Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A // Brain. 2013. Vol. 136, № 10. P. 3140–3150.
Sano T. yet al. MicroRNA-34a upregulation during seizure-induced neuronal death // Cell Death Dis. 2012. Vol. 3, № 3. P. ye287–ye287.
Blümcke, I., Thom, M., Aronica, Ye., Armstrong, D. D., Bartolomei, F., Bernasconi, A., Bernasconi, N., Biyen, C. G., Cendes, F., Coras, R.,
Cross, J. H., Jacquyes, T. S., Kahane, P., Mathern, G. W., Miyata, H., Moshé, S. L., Oz, B., Özkara, Ç., Perucca, Ye., … Spreafico, R. (2013).
International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods. Epilepsia, 54(7), 1315–1329. https://doi.org/10.1111/yepi.12220.
Nokkari A. yet al. Implication of the Kallikrein-Kinin system in neurological disorders: Quyest for potential biomarkers and mechanisms // Progress in Neurobiology. 2018. Vol. 165–167. P. 26–50.
Zattoni M. yet al. Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy // J. Neurosci. 2011. Vol. 31, № 11. P. 4037–4050.
Theodore W.H. yet al. Human herpes virus 6B: A possible role in epilepsy? // Epilepsia. 2008. Vol. 49, № 11. P. 1828–1837.
Sai M.-H. yet al. Yetiology of hippocampal sclerosis: Yevidence for a predisposing familial morphologic anomaly // Neurology. 2013. Vol. 81, № 2. P. 144–149.