ANALYSIS OF THE MAIN EMOTIONAL AND PERSONAL DYSFUNCTIONS IN PATIENTS WITH CHRONIC CEREBRAL ISCHEMIA (CСI)
Keywords:
chronic cerebral ischemia, emotional and personality disorders, neuropsychological profile, Spielberger-Khanin scale, hospital anxiety and depression scale, Montgomery-Asberg scaleAbstract
Purpose. To determine emotional and personal disorders in the examined patients with chronic cerebral ischemia, to evaluate their characteristics in different age groups.
Materials and methods. The data of a study of 170 patients with HCG (cerebrovascular pathology) (men (M) – 84/49.4%, women (W) – 86/50.1%) on the background of hypertension (GB) and atherosclerosis, aged 44-74 years (mean age (SV) 58.8±1.3 years) were studied. The neuropsychological profile was assessed using the Spielberger-Hanin anxiety Scale (State-Trait Anxiety Inventory – STAI), The Hospital Anxiety and Depression Scale –Anxiety – HADS-A) and depression (Depression – HADS-D), the Beck Depression Inventory Scale (BDI), Montgomery- The Montgomery-Asberg Depression Rating Scale –MADRS), the Zung Self-Rating Depression Scale (Z-SDS), and the subjective Asthenia Assessment Scale (MFI–20).
Results. The article presents the main mechanisms of development of chronic cerebral ischemia and features of neuropsychological manifestations. The data of our own observation and the evidence base on personality and emotional changes in middle-aged and elderly patients with CHIGM based on hypertension and atherosclerosis are presented. The results of the study are compared with a group of practically healthy people of proportional age.
Conclusions. The study found that with increasing age, there is an increase in the severity of changes in the neuropsychological profile in patients with CHIGM.
References
Абдулкадыров К.М., Шуваев В.А., Мартынкевич И.С. Что нам известно об истинной полицитемии (обзор литературы и собственные данные) //Онкогематология. 2015 10 (3). 28–42.
Громова О.А., Торшин И.Ю., Калачева А.Г. Тройственный синергизм этилметилгидроксипиридина сукцината, магния и витамина В6: молекулярные механизмы. Неврология, нейропсихология и психосоматика 2017;9(1):42-9
Камчатнов П.Р., Евзельман М.А., Морозова Ю.А. Возможности комбинированной терапии пациентов с хроническими расстройствами мозгового кровообращения. Поликлиника 2017;2-2:73-8.
Кобалава Ж.Д., Колесник В.Л., Троицкая Е. А. Современные европейские рекомендации по артериальной гипертонии: обновленные позиции и нерешенные вопросы. Клиническая фармакология и терапия 2019;28(2):7-17.
Путилина М.В. Нейропептидная терапия хронической ишемии мозга у пациентов пожилого возраста // Неврология и психиатрия
№4; 2014; -С. 44-49.
Маджидова Ё.Н., Ходжаева Д.Т., Хидоятова Д.Н., Жаббарова С.Б., Ким О.В. Применение холина альфосцерата при лечении больных с хронической ишемией мозга. Неврология. – Ташкент, 2019. - №3 – С. 85-88
Clinical guidelines. Senile asthenia. ICD-10: R-54. Age group: 60 and over]. Moscow; 2018. 106 p.
Gao Z, Thang H, Liu J, Lau SW, Liu P, Chen ZY, Lee HK, Tipoe GL, Ho HM, Yao X, Huang Y. Cyclooxygenace-2-dependent oxidative stress mediates palmitate-induced impartment of endothelium-dependent relaxations in mouse arteries. Biochemical Pharmacology 2014 Oct;91(4):471-82.
Griesshammer M., Kiladjian J.J., Besses C. Thromboembolic events in polycythemia vera. Ann. Hematol. 2019; 98(5): 1071–1082.
Davydkin. I. L., Kozlova N. S., Zolotovskaya I.A., Roitman E. V. Hypertension in patients with polycythemia vera: Focus on microcirculation. Arterial Hypertension. 2016. 22(6), P. 610–619.
Liisborg C., Hasselbalch H. C., Sørensen T. L. Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms. Cancers (Basel). 2020. Mar; 12(3): 573.
McFarland D.C., Shaffer K.M., Polizzi H. et al. Prevalence of Physical Problems Detected by the Distress Thermometer and Problem List in Patients with Myeloproliferative Disorder. J. Natl. Compr. Canc. Netw. 2017 Dec; 15(12): P. 1503–1508.
Michiels J.J, Berneman Z., Gadisseur A. et al. Aspirin-responsive, migraine-like transient cerebral and ocular ischemic attacks and erythromelalgia in JAK2-positive essential thrombocythemia and polycythemia vera. Acta Haematol – 2015;133(1) – P. 56–63.
Oganov RG, Simanenkov VI, Bakulin IG, et al. Comorbid pathology in clinical practice. Algorithms for diagnosis and treatment. Clinical guidelines. Kardiovaskulyarnaya terapiya i profilaktika. 2019;18(1):5-66.
Scherber R.M., Kosiorek H.E., Senyak Z. et al. Comprehensively understanding fatigue in patients with myeloproliferative neoplasms. // Cancer. 2016 Feb 1;122(3)/ P. 477–485.
Tanashyan M. M., Kuznetsova P. I., Subortseva I. N. et al. Chronic and acute cerebrovascular pathology in patients with Ph-negative myeloproliferative diseases. Hematology and Transfusiology. 2016; 61(3): 146–150.
Zyrina G V., Slyusar T.A. Clinical and neuroimaging features of chronic cerebral ischemia in polycythemia vera. Medical alphabet. 2021;
(3): 58–62. https://doi. org/10.33667/2078-5631-2021-3-58-62.
Matlyuba Sanoeva, Gulova Munisakhon. Comparative analysis of cognitive function at vascular complications of migraine. Diagnosis and clinical approach // BIO Web of Conferences 121, 03014 (2024) GLSBIA 2024. https://doi.org/10.1051/bioconf/202412103014.
Salim Davlatov, Rustam Navruzov, Matluba Sanoyeva, Dilshod Xudoykulov, Karim Gaziev. Morphometric changes in the walls and lymphoid structures of the colon in radiation sickness // BIO Web of Conferences 121, 03003 (2024) GLSBIA 2024 https://doi.org/10.1051/bioconf/202412103003.
Matlyuba Sanoeva, Naim A. Shamsiyev, Bakhodirjon T. Amanov et al. Role of SEL1L in the progression of solid tumors, with a special focus on its recent therapeutic potential //Cell Biol Int. 2024;1–17.
