PATHOGENETIC INTERCONNECTIONS OF INFLAMMATION, DYSLIPIDEMIA IN ATHEROTROMBOTIC DAMAGE OF EXTRACRANIAL ARTERIES
Keywords:
atherosclerosis, inflammation, dyslipidemia, extracranial arteries, atherothrombosis, pathogenesis, carotid arteries, vertebral arteries, cerebrovascular diseases, ischemic stroke, C-reactive protein, interleukins, low-density lipoproteins, endothelial dysfunction, atherosclerotic plaqueAbstract
Atherothrombotic damage to the extracranial arteries is one of the most important medical and social problems of our time, being the leading cause of the development of ischemic cerebrovascular events. According to the World Health Organization, cerebrovascular diseases rank second among the causes of death worldwide, leading to the death of more than 6.2 million people annually. In the structure of all strokes, ischemic disorders of cerebral circulation make up 80-85%, while atherosclerotic damage to the extracranial segments of the carotid and vertebral arteries is the cause of stroke development in 15-20% of cases.
References
Feigin V.L., et al. Global and regional burden of stroke during 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. 2021;20(10):795–820.
Sacco R.L., et al. Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack. Stroke. 2021;52:e364– e467.
North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med. 1991;325:445–453.
Hansson G.K. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352:1685–1695.
Libby P., et al. Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol. 2009;54(23):2129–2138.
Ridker P.M., et al. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000;342:836–843.
Ross R. Atherosclerosis — an inflammatory disease. N Engl J Med. 1999;340:115–126.
Goldstein L.B., et al. Guidelines for the primary prevention of stroke. Stroke. 2011;42:517–584.
Catapano A.L., et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias. Eur Heart J. 2020;41(1):111–188.
Ridker P.M. High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation. 2001;103:1813–1818.
Gupta A., et al. Carotid plaque MRI and stroke risk: a systematic review and meta-analysis. Stroke. 2013;44:3071–3077.
