IMPLIMENTATION OF “GREEN” CHEMISTRY PRINCIPLES IN PHASE MODIFICATION OF ACTIVE INGRIDINETS
Keywords:
“green” chemistry, phase modification, lyophilization, dihydroquercetin, solubilityAbstract
Implementation of eco-friendliness in drug design is one of the current trends in pharmacy. The phase modification of dihydroquercetin (DHQ) by lyophilization of water-alcohol solution was performed directed by the principles of “green” chemistry. This approach characterizes by appropriate values of process mass intensity and atom economy. Lyophilizate demonstrates fiber morphology and amorphous solid stage. The save of initial molecular structure of DHQ was confirmed by complex spectral analysis. It was shown, that phase modification results in enchantment of water solubility, while primarily, in 30 times, comparing with initial active pharmaceutical ingredient. At the same time, the antioxidant capacity of DHQ lyophilizate did not changed. So, this product is a promising object for the following research as lyophilized injection dosage form.
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