ANALYSIS OF ETILIOLOGICAL FACTORS AND CLINICAL MANIFESTATIONS OF IMMUNE THROMBOCYTOPENIA
Keywords:
immune thrombocytopenia, acute, chronic, hemorrhagic syndrome, corticosteroids, спленеcтомй, иммуносуппрессантс, тҳромбопоиэтин реcэптор агонистс, аналйсисAbstract
Immune thrombocytopenia (ITP) is a bleeding disorder typically not associated with anemia or leukopenia. In adults, it is typically chronic, but in children it is often acute and transient. Diagnosis is usually clinical, based on exclusion of other causes of thrombocytopenia (e.g., HIV infection, hepatitis). Treatment includes corticosteroids, splenectomy, immunosuppressants, thrombopoietin receptor agonists, or the spleen tyrosine kinase inhibitor fostamatinib. In cases of life-threatening bleeding, platelet transfusions, intravenous corticosteroids, intravenous anti-D immunoglobulin, or intravenous immunoglobulin, alone or in combination, should be administered. Immune thrombocytopenia (ITP) is a disease characterized by severe hemorrhagic syndromes, including life-threatening bleeding, which can be managed with etiotropic therapy, overcoming immunosuppressant resistance, and achieving stable remission. To achieve this, it is necessary to study the influence of various factors on the development of antiplatelet antibodies.
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