BOLALARDA ORTIQCHA VAZN VA SEMIZLIKNING BUYRAKLARGA TA’SIR MEXANIZMI
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semizlik, bolalar, buyrak holati##article.abstract##
Semizlik va metabolik sindrom bola organizmi tizimlarining funktsional holatiga ta'sir qilib, buyraklarning progressiv shikastlanishiga olib keladi va surunkali buyrak kasalligi rivojlanishida xavf omili hisoblanadi. Semizlikda buyrak shikastlanishining shakllanishi adipokin ishlab chiqarishning buzilishi, renin-angiotenzin tizimining faollashishi, surunkali yallig'lanish, dislipidemiya, buyrak gemodinamikasi buzilishi va tana vazniga nisbatan nefronlar sonining kamayishi bilan bog'liq. Ushbu omillarning uzoq muddatli ta'sir qilishi glomeruloskleroz va surunkali buyrak etishmovchiligining rivojlanishiga olib keladi. Bolalarda buyrak shikastlanishining dastlabki belgilari va biomarkerlarini aniqlash, buyrak shikastlanishining rivojlanishi va rivojlanishining oldini olish uchun zarur omil hioblanadi.Ushbu tadqiqotimizda biz bolalarda semizlik va ortiqcha tana vaznning buyrakning naychali apparati va glomerulyar filtratsiya tezligiga ta’sirini o’rganib chiqdik.
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