RENAL HEMODYNAMICS IN THE ABDOMINAL TYPE OF OBESITY IN CHILDREN AND ADOLESCENTS
Keywords:
obesity, children, microalbuminuria, renal hemodynamicsAbstract
We studied 35 obese children aged 7 to 18 years, as well as 20 children with normal body weight. A relationship was obtained between the severity of carbohydrate metabolism disorders, dyslipidemia in children and the level of microalbuminuria, which was expressed by an increase in the level of cholesterol, triglycerides, LDL and a decrease in HDL, an increase in immunoreactive insulin and an IR HOMA R index in children with high microalbuminuria. It was revealed that in children with obesity and microalbuminuria, violations of renal hemodynamics at the level of interlobar and arcuate renal arteries are determined. A statistically significant decrease in Vmin at the level of large renal vessels allows us to consider these changes as a marker of early renal hemodynamic disorders.
References
Всемирная организация здравоохранения. Ожирение и избыточный вес. Информационный бюллетень № 311. Январь 2015 г.
Lobstein T, Baur L, Uauy R. IASO International Obesit TaskForce. Obesity in children and young people: a crisis in public health. Obes Rev 2004; 5 Suppl 1: 4-104
Wang Y, Chen X, Song Y et al. Association between obesity and kidney disease: a systematic review and metaanalysis. Kidney Int 2008; 73: 19-33
Wahba IM, Mak RH. Obesity and obesity-initiated metabolic syndrome: mechanistic links to chronic kidney disease. Clin J Am Soc Nephrol 2007; 2: 550-562
Sarafidis PA, Ruilope LM. Insulin resistance, hyperinsulinemia, and renal injury: mechanisms and implications. Am J Nephrol 2006; 26: 232-244
Вялкова АА, Лебедева ЕН, Красиков С.И и др. Клинико патогенетические аспекты повреждения почек при ожирении (обзор литературы). Нефрология 2014; (3): 24-33 [Vyalkova AA, Lebedeva EN, Krasikov CI i dr. Kliniko-patogeneticheskie aspekty povrezdenia pochek pri ogirenii. Nephrologia 2014; (3): 24-33]
Дедов И.И, Мельниченко Г.А, Романцова Т.И. Патогенетические аспекты ожирения. Ожирение и метаболизм 2004; (1): 3–9 [Dedov II, Mel’nichenko GA, Romancova TI. Patogenet
