DISORDERS OF MINERAL METABOLISM AGAINST THE BACKGROUND OF INFLAMMATORY BOWEL DISEASES

Abstract

There is no ambiguous answer in the literature regarding the dynamics of markers of bone metabolism in IBD, and the direction of osteocalcin dynamics is unclear. It has been proven that one of the clinical complications of IBD is disorders of mineral metabolism, leading to osteopenia and osteoporosis. Therefore, patients with IBD should be regularly examined for the presence of pathology of mineral metabolism, Biochemical markers of bone metabolism, reflect the balance between bone resorption and remodeling. The pathogenesis of a decrease in bone mineral density in IBD is multifactorial. Levels of Ca and vitamin D can not only cause osteoporosis, but also initiate secondary hyperparathyroidism. In IBD patients, due
to the low concentration of vitamin D, the level of PTH is increased, while in most patients the concentrations of calcium and phosphates were within the normal range.