МЕСТО ФЕНОФИБРАТА В ЛЕЧЕНИИ БОЛЬНЫХ КОРОНАВИРУСОМ SARS-COV-2
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Ключевые слова

фенофибрат, SARS-CoV-2, ACE2, рецептор-связывающий домен (RBD), ИФА fenofibrate, SARS-CoV-2, ACE2, receptor-binding domain (RBD), IFA fenofibrat, SARS-CoV-2, ACE2, retseptorlarni bog’lovchi domen (RBD), IFA

Аннотация

Настоящая пандемия и тяжелый острый респираторный синдром (SARS-CoV-2) привели к значительному числу летальных исходов во всем мире. На сегодняшний день число смертельных случаев превышает 4.55.миллиона человек. Чтобы определить препараты для дополнительного эффективного  лечения инфекции SARS-CoV-2, был создан экран для измерения димеризации ангиотензин превращающего фермента 2 (ACE2), основного рецептора входа вируса в клетку. Этот экран идентифицировал фенофибриновую кислоту, активный метаболит фенофибрата. Фенофибриновая кислота также дестабилизировала рецептор-связывающий домен (RBD) спайкового белка вируса и ингибировала связывание RBD с ACE2 в иммуноферментном анализе (ИФА). Фенофибрат и фенофибриновая кислота были протестированы двумя независимыми лабораториями в Великобритании. В обоих случаях при концентрациях препарата в клинических дозах  фенофибрат и фенофибриновая кислота снижали вирусную инфекцию до 70% [15, 23]. Вместе с обширной историей клинического применения и относительно хорошим профилем безопасности это исследование определяет фенофибрат как потенциальное терапевтическое средство, требующее клинической оценки для лечения инфекции SARS-CoV-2 у коморбидных больных с артериальной гипертонией и высоким индексом массы тела, а также сахарным диабетом и ишемической болезнью сердца.

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