ORTIQCHA VAZNLI VA SEMIZ KISHILARDA TANA TARKIBI KO'RSATKICHLARI VA INSULINREZISTENTLIK INDEKSLARI O'RTASIDAGI BOG'LIQLIK
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Tana tarkibi, DXA, HOMA-IR, insulinrezistentlik, Matsuda indeksi##article.abstract##
Ma’lumki semizlik va ortiqcha vazn insulinrezistentlik va 2-tur Qandli diabet rivojlanishining xavf omillaridan sanaladi va yog’ to’qimasining organizmda taqsimlanishi bu metabolik xavf uchun muhim ahamiyatga ega. Materiallar va metodlar: Bu ko’ndalang tadqiqotda biz 66 ta ortiqcha tana vaznili va semiz bemorlarning ikki tomonlama roentgen absorbsiometriyasi usulida tekshirilgan tana tarkibi haqidagi ma’lumotlaridan foydalandik va natijalarni 2 xil insulinrezistentlik indekslari bilan korrelyatsiya qildik. Natijalar: Tadqiqot ishtirokchilarining 60%i ayollar bo’lib, o’rtacha yoshlari (standard xató) 30.1 (0.6) yosh, tana vazni indeksi 34.0 (0,6) kg/m2, insulinrezistentlikning gomeostatik modeli HOMA-IR 2,1 (0,2) va insulinga sezgirlik indeksi ISI Matsuda 5,8 (0,4). Ayollarda eng kuchli bog’liqliklar android-ginoidlarda (r = 0,52, p < 0,001 HOMA-IR uchun; r = 0,46, p < 0,001 Matsuda ISI uchun) kuzatildi. Erkaklarda esa kuchli korrelyatsiya android tipdagi semizlarda (r = 0,40, p = 0,01 HOMA-IR; r = 0,37, p = 0,02 Matsuda ISI uchun) kuzatildi. Visseral yog’ to’qimasi ayollarda ikkala indeks bilan ham bog’liq ekanligi, erkaklarda esa faqat Matsuda ISI bilan bog’liqligi aniqlandi. Erkaklarda ham , ayollarda ham tana vazni indeksi va HOMA-IR indeksi o’rtasidagi bog’liqlik qayd etildi. Xulosa: kamharakat semiz yoki ortiqcha vaznli kishilarda ikki tomonlama rentgen absorbsiometriyasi usulida aniqlangan regionar semizlik insulinrezistentlik ko’rsatkichlari bilan korrelyatsiyalanadi.
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