O’G’IL BOLADA PILOTSITAR ASTROTSITOMA BILAN ASSOTSIRLANGAN MARKAZIY ERTA JINSIY NRIVOJLANISH HOLATI HAQIDA HISOBOT
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erta jinsiy rivojlanish, markaziy erta jinsiy rivojlanish, gipotalamo-gipofizar-gonadal o’q, telarxe, pubarxe, Tanner bosqichi, optic glioma, astrotsitoma, ependimoma, medulloblastoma, gipotalamik gamartoma, gidrosefaliya, serebral ishemiya, pilotsitar astrotsitoma, Prader orxidometriyasi, xiazma-sellar soha##article.abstract##
Kirish. Markaziy erta jinsiy rivojlanish deganda gipotalamus-gipofizar-gonadal o’qining erta faollashishi tushuniladi, buning natijasida ikkilamchi jinsiy xususiyatlar qizlarda 8 yoshgacha, o’g’il bolalarda 9 yoshdan avval paydo bo’ladi. Markaziy erta jinsiy rivojlanish aniqlangan bemorlarda MRT tasvirlarida o’smalarning quyidagi turlari aniqlanadi: astrositoma, ko’ruv nervi gliomasi, kraniofaringioma, gipotalamik o’smalar, ko’prik o’smalari, suprasellar o’smalar, to’rtinchi qorincha o’smalari, pineal o’smalar, neyroblastoma, germinogen o’smalar, retinoblastoma, gipofiz makroadenomasi, Ewing sarkomasi, Burkitt limfomasi va langergans hujayrali gistiotsitoz. Klinik holat taqdimoti. Ushbu maqolada biz 2 yoshida operatsiya qilingan, jinsiy rivojlanishi 4 yosh 6 oyligida boshlangan pilotsitar astrotsitoma bilan og’rigan o’g’il bolaning holatini taqdim etamiz. Hozirgi vaqtda bemor har 4 haftada 3,75 mg triptorelin atsetatni doimiy ravishda qabul qilmoqda, ikkilamchi jinsiy rivojlanish belgilari yo’q. Muhokama va xulosa. Bizning xabar qilingan holatda, pilotsitar astrotsitomaning umurtqa pog’onasiga metastazlanganligi kuzatilganligi sababli, bemorda xiazma-sellar sohadagi o’smani olib tashlash va bir qator kimyoterapiya muolajalari o’tkazildi. 3,5 yil o’tgach, bola 4,5 yoshga to’lganda, ikkilamchi jinsiy rivojlanish belgilari paydo bo’ldi. Urug’donlarning simmetrik kattalashishi, bazal va stimullangan LG miqdorining yuqoriligi, suyak yoshining 4 yilga oldinlab ketishi, erta jinsiy rivojlanishning boshqa shakllarini istisno qilgan holda, bemorga Markaziy erta jinsiy rivojlanish tashxisi qo’yildi. Bundan tashqari, bemor bolalar onkologi nazorati ostida, 6 oylik dinamik kuzatuv mobaynoda bolada o’sma o’sishining klinik va rentgenologik belgilari aniqlanmadi.
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