ИДИОПАТИК ПАСТ БЎЙЛИ БЕМОРЛАРДА СУЯК МЕТАБОЛИЗМИНИНГ ХУСУСИЯТЛАРИ
##article.subject##:
низкорослость, остеопороз, гормон роста, инсулиноподобный фактор роста-1, андроген, эстроген##article.abstract##
Идиопатик паст бўйли беморларда суяк метаболизми билан боғлиқ масалаларни ўрганиш жуда муҳим, чунки болалар ва ўсмирлардаги ўсиш бузилиши кўпинча суяк минерал зичлигининг ўзгариши билан кечади, бу эса узоқ муддатли асоратларга олиб келиши мумкин (остеопения, остеопороз ва бошқалар). Бундан ташқари, фаол балоғат даврида, шунингдек ўсмирлик даврида тенгдошларидан сезиларли даражада орқада қолиши билан боғлиқ клиник ва психологик муаммолар кузатилиши мумкин. Бугунги кунда эндокрин патологиялари бўлган болаларда суяк тўқималарининг метаболизмига бағишланган бир қатор тадқиқотлар мавжуд. Шу билан бирга, идиопатик паст бўйликнинг турли шаклларини ва уларнинг суяк метаболизмининг бузилиши билан боғлиқлигини батафсил кўриб чиқадиган ишлар доираси жуда чекланган. Ушбу шарҳнинг мақсади идиопатик паст бўйли бўлган беморларда суяк метаболизмининг бузилиши ривожланишининг патогенези масалаларини адабиёт маълумотлари асосида ўрганишдир.
Библиографические ссылки
C. Ohlsson, D. Mellstro ̈m, D. Carlzon et al., “Older men with low serum IGF-1 have an increased risk of incident fractures: the MrOS Sweden study,” Journal of Bone and Mineral Research, vol. 26, no. 4, pp. 865–872, 2011.
Ceylan, M.N.; Akdas, S.; Yazihan, N. Is Zinc an Important Trace Element on Bone-Related Diseases and Complications? A Meta-analysis and Systematic Review from Serum Level, Dietary Intake, and Supplementation Aspects. Biol. Trace Elem. Res. 2021, 199, 535–549.
Chen J.F., Lin P.W., Tsai Y.R., Yang Y.C., Kang H.Y. Androgens and Androgen Receptor Actions on Bone Health and Disease: From Androgen Deficiency to Androgen Therapy. Cells. 2019;8:1318. doi: 10.3390/cells8111318
Cohen P, Rogol AD, Deal CL, et al. Consensus Statement on the Diagnosis and Treatment of Children with Idiopathic Short Stature: A Summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Pediatric Endocrinology Workshop. J Clin Endocrinol Metab. 2008;93(11):4210–4217.
Emmanuelle N.E., Marie-Cécile V., Florence T., Jean-François A., Françoise L., Coralie F., Alexia V. Critical Role of Estrogens on Bone Homeostasis in Both Male and Female: From Physiology to Medical Implications. Int. J. Mol. Sci. 2021;22:1568. doi: 10.3390/ijms22041568.
Gayretli Aydin ZG, Bideci A, Emeksiz HC, Çelik N, Döğer E, Bukan N, Yildiz U, Camurdan OM, Cinaz P. Assessment of bone turnover markers and bone mineral density in normal short boys. J Pediatr Endocrinol Metab. 2015 Nov 1;28(11-12):1321-6. doi: 10.1515/jpem-2014-0099. PMID: 26197459.
Grossman, A., Ismailov, S., Kulmirzayeva, M., Urmanova, Y., & Gilazitdinov, K. (2019). Constitutional delay of growth and puberty in boys: review. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), 15(5), 402–409. https://doi.org/10.22141/2224-0721.15.5.2019.180045
Hesse, E.; Kiviranta, R.; Wu, M.; Saito, H.; Yamana, K.; Correa, D.; Atfi, A.; Baron, R. Zinc finger protein 521, a new player in bone formation. Ann. N. Y. Acad. Sci. 2010, 1192, 32–37.
Huang, T.; Yan, G.; Guan, M. Zinc Homeostasis in Bone: Zinc Transporters and Bone Diseases. Int. J. Mol. Sci. 2020, 21, 1236
Iaquinta M.R., Lanzillotti C., Mazziotta C., Bononi I., Frontini F., Mazzoni E., Oton-Gonzalez L., Rotondo J.C., Torreggiani E., Tognon M., et al. The role of microRNAs in the osteogenic and chondrogenic differentiation of mesenchymal stem cells and bone pathologies. Theranostics. 2021;11:6573–6591. doi: 10.7150/thno.55664
Khizhnyak OO, Mikityuk MR, Barabash NE, Nikolaev RS, Manskaya EH. Screening of hormone-producing pituitary adenomas (Review of literature and own data). Problems of Endocrine Pathology. 2018;4:91-102. doi: 10.21856/j-PEP.2018.4.10.
Li, H.; Li, M.; Ran, X.; Cui, J.; Wei, F.; Yi, G.; Chen, W.; Luo, X.; Chen, Z. The Role of Zinc in Bone Mesenchymal Stem Cell Differentiation. Cell Reprogram. 2022, 24, 80–94.
Liang, D.; Yang, M.; Guo, B.; Cao, J.; Yang, L.; Guo, X. Zinc Upregulates the Expression of Osteoprotegerin in Mouse Osteoblasts MC3T3-E1 Through PKC/MAPK Pathways. Biol. Trace Elem. Res. 2012, 146, 340–348.
Locatelli V, Bianchi VE. Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis. Int J Endocrinol. 2014;2014:235060. doi: 10.1155/2014/235060. Epub 2014 Jul 23. PMID: 25147565; PMCID: PMC4132406.
Mazzoni E., Mazziotta C., Iaquinta M.R., Lanzillotti C., Fortini F., D’Agostino A., Trevisiol L., Nocini R., Barbanti-Brodano G., Mescola A., et al. Enhanced Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by a Hybrid Hydroxylapatite/Collagen Scaffold. Front. Cell Dev. Biol. 2021;8:610570. doi: 10.3389/fcell.2020.610570.
Muñoz-Garach, A.; García-Fontana, B.; Muñoz-Torres, M. Nutrients and Dietary Patterns Related to Osteoporosis. Nutrients 2020, 12
Park, K.H.; Choi, Y.; Yoon, D.S.; Lee, K.-M.; Kim, D.; Lee, J.W. Zinc Promotes Osteoblast Differentiation in Human Mesenchymal Stem Cells Via Activation of the cAMP-PKA-CREB Signaling Pathway. Stem Cells Dev. 2018, 27, 1125–1135
R.T. Hamza, A.I. Hamed, M.T. Sallam, Effect of zinc supplementation on growth hormone-insulin growth factor axis in short Egyptian children with zinc deficiency. Ital. J. Pediatr. 38, 21 (2012). doi:10.1186/1824-7288-38-21
Rakhimova, G., & Gilyazetdinov, K. (2018). Comparative efficacy of mono- and combined therapy for idiopathic short stature with delayed puberty. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), 14(3), 240–244. https://doi.org/10.22141/2224-0721.14.3.2018.136420
Sprio, S.; Dapporto, M.; Preti, L.; Mazzoni, E.; Iaquinta, M.R.; Martini, F.; Tognon, M.; Pugno, N.M.; Restivo, E.; Visai, L.; et al. Enhancement of the Biological and Mechanical Performances of Sintered Hydroxyapatite by Multiple Ions Doping. Front. Mater. 2020, 7, 224.
Udagawa N., Koide M., Nakamura M., Nakamichi Y., Yamashita T., Uehara S., Kobayashi Y., Furuya Y., Yasuda H., Fukuda C., et al. Osteoclast differentiation by RANKL and OPG signaling pathways. J. Bone Miner. Metab. 2021;39:19–26. doi: 10.1007/s00774-020-01162-6.
V. Ekbote, A. Khadilkar, S. Chiplonkar, Z. Mughal, V. Khadilkar, Enhanced effect of zinc and calcium supplementation on bone status in growth hormone-deficient children treated with growth hormone: a pilot randomized controlled trial. Endocrine (2012). doi: 10.1007/s12020-012-9847-0
Yang H, Yan K, Yuping X, Zhang Q, Wang L, Gong F, Zhu H, Xia W, Pan H. Bone microarchitecture and volumetric bone density impairment in young male adults with childhood-onset growth hormone deficiency. Eur J Endocrinol. 2019 Feb 1;180(2):145-153. doi: 10.1530/EJE-18-0711. PMID: 30481154; PMCID: PMC6347261.
Yusa, K.; Yamamoto, O.; Iino, M.; Takano, H.; Fukuda, M.; Qiao, Z.; Sugiyama, T. Eluted zinc ions stimulate osteoblast differentiation and mineralization in human dental pulp stem cells for bone tissue engineering. Arch. Oral Biol. 2016, 71, 162–169.
Классификация, диагностика и лечение идиопатической низкорослости Алексей Николаевич Шандин, Валентина Александровна Петеркова https://www.probl-endojournals.ru/jour/article/view/11131?locale=ru_RU
