НАТРИЙ-ГЛЮКОЗА КО-ТРАНСПОРТЁРИ ХАКИДА НИМАЛАР МАЪЛУМ?
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натрий-глюкоза ко-транспортери 1 тип ингибиторлари, натрий-глюкоза ко-транспортери 2 тип ингибиторлари, қандли диабет 2 тип, канаглифлозин, сотаглифлозин, мизаглифлозин##article.abstract##
Кўплаб илмий изланишлардан малумки, қандли диабет 2 (ҚД2) тип билан оғрийдиган беморларда натрий-глюкоза ко-транспортери 2 ингибиторлари (НГЛТ2), қондаки глюкоза миқдорини камайтириш, кардио ва ренопротекция хусусиятларига эга. НГЛТ1 тип эса нисбатан кам ўрганилган бўлиб, унинг активлигини бошқариш ҚД2 типни, юрак ва буйракнинг сурункали касалликларини компенсация қилишда муҳим роль эгаллаши мумкин. Хозирги кунда НГЛТ1 ни блоклаш факатгина НГЛТ1 ва НГЛТ2 ингибиторлари комбинацияси ёрдамида амалга ошириш мумкин. НГЛТ1 нинг селектив ингибиторлари экспериментал хайвонларда ва in vivo шароитида кенг ўрганиб борилмоқда. Мазкур шарҳ НГЛТ1 таъсир механизми ва уни блоклашнинг патологик жараёнларга таъсири, хамда одамларда ушбу препаратларнинг қулланиш истиқболлари хақида.
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