DYNAMICS OF NEUROIMAGING INDICATORS DURING RADIATION THERAPY FOR ACROMEGALY
Keywords:
radiation therapy, magnetic resonance imaging, pituitary adenoma, growth hormoneAbstract
Purpose of the study. To study the efficacy of radiation therapy in acromegaly and to evaluate neuroimaging indices in remote periods of therapy. The object of the study was 50 patients who were on radiation therapy. The results of the study showed that in 54% of patients the pituitary sizes recovered to normal, in 10% they decreased, but did not reach the target values, and in 16% there was no significant change in the size of the adenoma. Moreover, in 26% of the patients empty turkish sellar developed secondarily and in 36% post-radiation encephalopathy.
References
Freda Pamela U., Katznelson L., van der Lely A.J. et al. Long-acting somatostatin analog therapy of acromegaly: a meta-analysis. J Clin Endocrinol Metab 2005;90:8:4465—4473.
Grigoriev A., Molitvoslovova N., Marova E // Results of treatment of patients with pituitary somatotroph adenomas/.// 9th European Congress of Endocrinology.
Melmed S., Casanueva F.F., Cavagnini F. et al. Consensus. Guidelines for acromegaly management. J Clin Endocrinol Metab 2002; 87: 9: 4054—4058. Muller A.F., Kopchick J.J., Flyvbjerg A. et al. Clinical review 166.Growth Hormone Receptor Antagonists. J Clin Endocrinol Metab2004;89:4:1503—1511.
Melmed S., Colao A., Barkan A., Malich M., Grossman A.B., Kleinberg D., Clemmons D., Chanson P., Lavs F., Sehlechie J., Vance M.L., Ho K., Giustina A., Guidelines for Acromegaly Menegement An Update. J ClinEndocrinolMetab. 2010, 94. 5, 1509-1507.
Ostrom QT, Cioffi G, Gittleman H, et al. CBTRUS Sta tistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012 2016. Neuro Oncol 2019;21(suppl 5):v1–v100.
Park M, Lee SK, Choi J, et al. Differentiation between Cystic Pituitary Adenomas and Rathke Cleft Cysts: A Diagnostic Model Using MRI. AJNR Am J Neuroradiol 2015;36(10):1866–1873.
Su CQ, Zhang X, Pan T, et al. Texture Analysis of High b-Value Diffusion-Weighted Imaging for Evaluating Consis tency of Pituitary Macroadenomas. J Magn Reson Imaging 2020;51(5):1507–1513.
Tominaga JY, Higano S, Takahashi S. Characteristics of Rathke’s cleft cyst in MR imaging. Magn Reson Med Sci 2003;2(1):1–8.
Thompson LD, Seethala RR, Müller S. Ectopic sphenoid sinus pituitary adenoma (ESSPA) with normal anterior pituitary gland: a clinicopathologic and immunophenotypic study of 32 cases with a comprehensive review of the English literature. Head Neck Pathol 2012;6(1):75–100.