CHANGED LEVELS OF INTERLEUKIN-6 IN PARKINSON'S DISEASE PATIENTS WITH COVID-19
Keywords:
Covid-19 infection, Parkinson's disease,Abstract
The coronavirus disease (COVID-19) pandemic has attracted greater attention than ever before to the problems of immunopathology of human diseases, many of which are reflected in the study of neurodegenerative diseases. COVID-19 has clearly shown that one of the most significant targets of the RNA virus SARS-CoV-2 is the nervous system. Of particular interest is the relationship between COVID-19 and neurodegenerative diseases, including Parkinson's disease (PD). Parkinson's disease, according to its classical definition, is a chronic, progressive neurodegenerative disease. Currently, diagnosis is possible only with the development of motor symptoms (stiffness, oligo-, brady-, akinesia, rest tremor). The new coronavirus infection SARS-CoV-2 has neurotropic properties, and to date, cases of the development of delirium, meningitis, encephalitis, and acute transverse myelitis at the onset and/or against the background of the advanced course of COVID-19 have been described. Coronavirus can lead to an excessive, unregulated immune response in the host body - cytokine release syndrome. Increasingly, information is being heard that this type of immune response is an integral part of the development of target organ dysfunction and one of the main factors of morbidity. Immunological mechanisms in patients who have had Covid-19 have unique features. Uncontrolled production of cytokines by innate and acquired immune cells leads to the development of a “cytokine storm”. This work characterizes changes in the amount of immunological cytokines - interleukin-6 (IL-6) in Parkinson's disease. The impact of Covid-19 infection on the clinical course of Parkinson's disease, as well as the risk factor for the development of parkinsonism, is discussed.
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Статья поступила в редакцию 03.03.2024; одобрена после рецензирования 20.04.2024; принята к публикации 26.04.2024.
The article was submitted 03.03.2024; approved after reviewing 20.04.2024; accepted for publication 26.04.2024.
Информация об авторах:
Муминов Бекзод Аскарович, Ташкентская медицинская академия. Ташкент, Узбекистан. Е-mail: muminov-bekzod@list.ru, https://orcid.org/0009-0007-2744-9165
Матмуродов Рустамбек Жуманазарович- д.м.н., профессор. Ташкентская медицинская академия. Ташкент, Узбекистан. Е-mail: nevropatolog@mail.ru, https://orcid.org/0000-0003-2666-3286
Халимова Ханифа Мухсиновна- д.м.н., профессор. Ташкентская медицинская академия. Ташкент, Узбекистан. Е-mail: hanifa1948@bk.ru, https://orcid.org/0000-0001-7247-6110
Назарова Мадинабону Фаридовна- магистр, Ташкентская медицинская академия. Ташкент, Узбекистан. Е-mail: m.f.nazarova1217@gmail.com, https://orcid.org/0009-0009-9483-6071
Умирова Сурайё Мамуржоновна- PhD, Самаркандский государственный медицинский университет. Самарканд, Узбекистан. Е-mail: lenuraumirova@gmail.com, https://orcid.org/0009-0001-1538-3791.
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Матмуродов Р.Ж., Халимова Х.М. — идеологическая концепция работы, написание текста; редактирование статьи;
Муминов Б.А., Умирова С.М., Назарова М.Ф. — сбор и анализ источников литературы, написание текста.
Information about the authors:
Muminov Bekzod Askarovich, Tashkent medical academy. Tashkent, Uzbekistan. Е-mail: muminov-bekzod@list.ru, https://orcid.org/0009-0007-2744-9165
Matmurodov Rustambek Jumanazarovich- DSc, Professor. Tashkent medical academy. Tashkent, Uzbekistan. Е-mail: nevropatolog@mail.ru, https://orcid.org/0000-0003-2666-3286
Хаlimova Xanifa Muxsinovna- DSc, Professor. Tashkent medical academy. Tashkent, Uzbekistan. Е-mail: hanifa1948@bk.ru, https://orcid.org/0000-0001-7247-6110
Nazarova Madinabonu Faridovna- master, Tashkent medical academy. Tashkent, Uzbekistan. Е-mail: m.f.nazarova1217@gmail.com, https://orcid.org/0009-0009-9483-6071
Umirova Surayyo Mamurjonovna- PhD, Samarkand state medical university. Samarkand, Uzbekistan. Е-mail: lenuraumirova@gmail.com, https://orcid.org/0009-0001-1538-3791.
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the authors:
Matmurodov R.J., Xalimova X.M.— ideological concept of the work, writing the text; editing the article;
Muminov B.A., Umirova S.M., Nazarova M.F.— collection and analysis of literature sources, writing the text.
