ENDOSCOPIC REMISSION OF CLINICAL STEROID-DEPENDENT AND STEROID-RESISTANT FORMS OF NON-SPECIFIC ULCERATIVE COLITIS DURING COMPLEX TREATMENT WITH PLASMAPHERESIS
Keywords:
Nonspecific ulcerative colitis, steroid-dependent and steroid-resistant forms, plasmapheresisAbstract
The work analyzed clinical material based on the results of a comprehensive examination and treatment of 102 patients with a confirmed diagnosis of ulcerative colitis. The positive dynamics of general clinical, laboratory parameters and endoscopic picture in patients with steroid-dependent and steroid-resistant forms of ulcerative colitis when a course of extracorporeal plasmapheresis is used for their treatment indicates its effectiveness in stopping the exacerbation of the disease. Despite the use of minimal doses of corticosteroids during plasmapheresis sessions, compared with standard therapy, patients with steroid-dependent and steroid-resistant forms of ulcerative colitis achieve remission more often (from 22% to 96%), complications from long-term use are significantly reduced corticosteroids, the possibility of complete abolition of maintenance therapy has been achieved, which ultimately leads to an improvement in the quality of life of this category of patients.
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Статья поступила в редакцию 05.01.2024; одобрена после рецензирования 18.02.2024; принята к публикации 20.02.2024.
The article was submitted 05.01.2024; approved after reviewing 18.02.2024; accepted for publication 20.02.2024.
Информация об авторах:
Шодмонов Акбар Акрамович - соискатель кафедрый Хирургических болезней №1. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. Е-mail: akbarshodmonov@gmail.com, https://orcid.org/my-orcid?orcid=0009-0000-4190-5488
Курбаниязов Зафар Бабажанович- д.м.н., профессор, заведующе кафедрой Хирургических болезней №1. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. Е-mail: dr_zafar@list.ru, https://orcid.org/0000-0002-5725-6088
Аскаров Пулат Азадович - PhD, Заведующий курсом малоинвазивной и лапароскопической хирургии факультета последипломного образования Самаркандского государственного медицинского университета, Самарканд, Узбекистан. Е-mail: Pulat0513@gmail.com, https://orcid.org/0000-0003-4542-1442
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Курбаниязов З.Б. — идеологическая концепция работы, написание текста;
Аскаров П.А.-редактирование статьи;
Шодмонов А.А. — сбор и анализ источников литературы, написание текста.
Information about the authors:
Shodmonov Akbar Akramovich - applicant for the Department of Surgical Diseases No. 1. Samarkand State Medical University, Samarkand, Uzbekistan. E-mail: akbarshodmonov@gmail.com, https://orcid.org/my-orcid?orcid=0009-0000-4190-5488
Kurbaniyazov Zafar Babajanovich - Doctor of Medical Sciences, Professor, Head of the Department of Surgical Diseases No. 1. Samarkand State Medical University, Samarkand, Uzbekistan. E-mail: dr_zafar@list.ru, https://orcid.org/0000-0002-5725-6088
Askarov Pulat Azadovich - PhD, Head of the course of minimally invasive and laparoscopic surgery, Faculty of Postgraduate Education, Samarkand State Medical University, Samarkand, Uzbekistan. E-mail: Pulat0513@gmail.com, https://orcid.org/0000-0003-4542-1442
Sources of funding: The work did not have special funding.
Conflict of interest: The authors declare the absence of obvious and potential conflicts of interest related to the publication of this article.
Contribution of the authors:
Kurbaniyazov Z.B. — the ideological concept of the work, writing the text;
Askarov P.A.-editing the article;
Shodmonov A.A. — collection and analysis of literature sources, writing a text.
