ANALYSIS OF THE RESULTS OBTAINED AND SOME FEATURES OF CYTOKINE PROFILE IN MIXED SALIVA OF PATIENTS WITH GASTROINTESTINAL TRACT DISEASE

Abstract

Objective: To study the obtained data and some features of cytokine profile in mixed saliva of patients with gastrointestinal tract disease

Methods: 140 patients with gastrointestinal tract pathology were examined, including 98 men (70%) and 42 women (30%), mean age - 51.9 years. According to endoscopic examination, the patients had lesions of different parts of the GI tract (chronic gastritis; peptic ulcer disease of the stomach and 12-peritoneum). The control group included 25 practically healthy individuals. Diagnosis of the lesion of different GIT departments was based on classical criteria and was carried out taking into account clinical-endoscopic, functional and morphological data Verification of chronic gastritis was carried out according to classification signs.

Obtained results: it was found that the spectrum of oral cavity lesions in various concomitant diseases is wide. At the same time, they develop pathological conditions in oral cavity tissues, and on their background there is a reception of various preparations for their own correction.

Conclusions. Thus, the level of interleukin-4 in the mixed saliva of patients with GI disease decreased by 23% relative to the comparison group data. At the same time, the level of IL-6 in the mixed saliva of the examined patients exceeded the initial level in 2.4 times. IL-6 is known to be an inducer of inflammatory reaction and triggers the synthesis of acute phase proteins in the liver (C-reactive protein, serum amyloid A, etc.), as well as reduces the production of fibronectin, albumin and transferrin in the liver. The key anti-inflammatory factor IL-10. is known to inhibit the production of TNFα, IL-1β and IL -6 and inhibit the expression of major histocompatibility complex class II.