• RAKHIMOV Nodir Makhammatkulovich
  • ABDURAKHMONOV Jurabek Amrilloevich
  • SHAKHANOVA Shakhnoza Shavkatovna
  • SULIMOVA Olga Gennadevna


ovarian cancer, recurrence, malignant ascites, intraperitonal metastasis


Diagnostic approach and treatment of recurrent ovarian cancer has many unresolved issues, the relevance of which is associated with late diagnosis and ultimately low treatment effectiveness and high mortality rates. The clinical manifestation of recurrent ovarian cancer is variable even within a morphologically similar group of patients due to the high degree of heterogeneity of the tumor. Questions remain about how wide the range of molecular genetic markers is and what is the correlation between their level and the effectiveness of treatment for ovarian cancer recurrence. One of the most promising ways to obtain information about the nature of the recurrence of the tumor process in ovarian cancer (OC) can be the study of ascitic fluid (AF).


Ahmed N., Stenvers K.L. Getting to know ovarian cancer ascites: opportunities for targeted therapy‑based translational research. Front Oncol. 2013 Sep 25; 3: 256. doi: 10.3389/fonc.2013.00256.

Ardatskaya M.D. Ascites and peritonitis in the practice of therapist and gastro‑ enterologist. Consilium Medicum. 2009; 11 (8): 51–60. (in Russian).

Abdurakhmonov Jurabek, Rahimov Nodir, Shakhanova Shakhnoza. Modern view on ascite in ovarian cancer. Journal of Biomedicine and Practice. 2022, vol. 7, issue 4, pp. 130-139

Caitlin Hodge, Brian D Badgwell Palliation of Malignant Ascites Surg Oncol 2019 Jul;120(1):67-73 doi: 10.1002/jso.25453. Epub 2019 Mar 22. DOI: 10.1002/jso.25453/

Cosmin Caraiani, Dong Yi, Bianca Petresc, Christoph Dietrich Indications for abdominal imaging: When and what to choose? J Ultrason 2020; 20: e43–e54 DOI: 10.15557/JoU.2020.0008

Elisabeth Smolle, Valentin Taucher Malignant ascites in ovarian cancer and the role of targeted therapeutics// Anticancer research 34: 1553-1562 (2014) review.

European Association for the Study of the Liver. EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis. J Hepatol. 2010 Sep; 53 (3): 397–417. doi: 10.1016/j.jhep.2010.05.004.

Gopi M, Hanifah M. A comparative study of serum ascitic fluid albumin gradient with ascitic fluid total protein in evaluating the etiology of ascites. Int J Adv Med 2019;6: 1259-61 DOI: 10.18203/2349-3933.ijam20193281

Guo L., Guo N. Exosomes: potent regulators of tumor malignancy and potential bio‑tools in clinical application. Crit Rev Oncol Hematol. 2015 Sep; 95 (3): 346–58. doi: 10.1016/j.critrevonc.2015.04.002.

Ho C.M., Chang S.F., Hsiao C.C., Chien T.Y., Shih D.T. Isolation and characterization of stromal progenitor cells from ascites of patients with epithelial ovarian adenocarcinoma. J Biomed Sci. 2012 Feb 14; 19: 23. doi: 10.1186/1423‑0127‑19‑23.

Julie L.Hentze, Claus Høgdall, Susanne K.Kjær, Jan Blaakær, Estrid Høgdall Searching for new biomarkers in ovarian cancer patients: Rationale and design of a retrospective study under the Mermaid III project// Contemporary Clinical Trials Communications Volume 8, December 2017, Pages 167-174].

Kipps Е., Tan D.S.P., Kayе S.B. Meeting the challenge of ascites in ovarian cancer: new avenues for therapy and research. Nat Rev Cancer. 2013 Apr; 13 (4): 273–82. doi: 10.1038/nrc3432;

Rizaev J.A, Rahimov N.M., Kadirov X.X., Shaxanova Sh.Sh. (2023). Oncoepidemiological assessment of the incidence and mortality of prostate cancer for the period 2015-2020 in the cross section of the republic of uzbekistan and individual regions. Open Access Repository, 4(3), 1108–1113.

Shakhanova Sh. Shakhnoza, Rakhimov M. Nodir. Aspects of sarcopenia syndrome in oncological practice: diagnosis and treatment (literature review) // Journal of Biomedicine and Practice. 2023, vol. 8, issue 3, pp. 406-417

Maksudov Dilshod D., Musurmanov Fazliddin I. et al. "Development of a Comprehensive Programme for the Comprehensive Treatment of Patients with Maxillofacial Phlegmon with Viral Hepatitis B." JournalNX, vol. 7, no. 02, 2021, pp. 191-198.

Rakhimov M. Nodir, Khudayberdiyeva A. Shohista, Oripova R. Mehriniso, Shakhanova Sh. Shakhnoza. Practical recommendations forNutritional support for cervical cancer// Journal of Biomedicine and Practice. 2023, vol. 8, issue 2,pp.224-230

Larissa Meyer , Rudy Suidan, Charlotte Sun, Shannon Westin, Robert L Coleman The management of malignant ascites and impact on quality of life outcomes in women with ovarian cancer// Expert Review of Quality of Life in Cancer Care. Author manuscript; available in PMC 2019 March 20. doi:10.1080/23809000.2016.1185369.

Latifi A., Luwor R.B., Bilandzic M., Nazaretian S., Stenvers K., Pyman J., Zhu H., Thompson E.W., Quinn M.A., Findlay J.K., Ahmed N. Isolation and characterization of tumor cells from the ascites of ovarian cancer patients: molecular phenotype of chemoresistant ovarian tumors. PLoS One. 2012; 7 (10): e46858. doi: 10.1371/journal.pone.0046858

Marie-France Penet,Balaji Krishnamachary, Flonné B. Wildes, Yelena Mironchik, Chien-Fu Hung, TC Wu Ascites Volumes and the Ovarian Cancer Microenvironment Front. Oncol., 17 December 2018 |

Oumer Abdu Muhie Causes and Clinical Profiles of Ascites at University of Gondar Hospital, Northwest Ethiopia: Institution-Based Cross-Sectional Study // Can J Gastroenterol Hepatol. 2019; 2019: 5958032. Published online 2019 Jul 8. doi: 10.1155/2019/5958032

Radomir Živadinović, Aleksandra Petrić, Dane Krtinić (November 29th 2017). Ascitic Fluid in Ovarian Carcinoma – From Pathophysiology to the Treatment, Ascites - Physiopathology, Treatment, Complications and Prognosis, Luis Rodrigo, IntechOpen, DOI: 10.5772/intechopen.70476

Shield K., Ackland M.L., Ahmed N., Rice G.E. Multicellular spher‑ oids in ovarian cancer metastases: Biology and pathology. Gynecol Oncol. 2009 Apr; 113 (1): 143–8. doi: 10.1016/j.ygyno.2008.11.032.

Smolle E., Taucher V., Haybaeck J. Malignant Ascites in Ovarian Cancer and the Role of Targeted Therapeutics. Anticancer Res. 2014 Apr; 34 (4): 1553–614

Stepanov I.V ., Paderov Yu.M., Afanasyev S.G. Peritoneal carcinomatosis. Siberian Journal of Oncology. 2014; 5: 45–53. (in Russian).

Stepanov S.O., Mitina L.A., Guts O.V., Bespalov P.D. Ultrasound imaging of peritoneal dissemination. Diagnostic radiology and radiotherapy. 2013; 3 (4): 66–70. (in Russian)

Tan D.S., Agarwal R., Kaye S.B. Mechanisms of transcoelomic metastasis in ovarian cancer. Lancet Oncol (2006) 7 (11): 939–1. doi: 10.1016/S1470‑2045(06)70939‑1.

Villert A.B., Kolomiets L.A., Yunusova N.V., Ivanova A.A. Ascites as a subject of studies in ovarian cancer. Siberian Journal of Oncology. 2019; 18 (1): 116–123. – doi: 10.21294/1814-4861-2019-18-1-116-123.

Yunusova N.V., Tamkovich S.N., Stakheeva M.N., The characterization of exosomes from biological fluids of patients with different types of cancer. AIP Conference Proceedings 1882; 2017: 020080. doi: 10.1063/1.50016597.

Wondim Getnet, Tesfaye Kebede , Asfaw Atinafu , Amir Sultan The Value of Ultrasound in Characterizing and Determining the Etiology of Ascites // Ethiop J Health Sci . 2019 май; 29 (3): 383–390. doi: 10.4314 / ejhs.v29i3.11