MORPHOLOGICAL AND FUNCTIONAL FEATURES OF THE STRUCTURE OF THE BRONCHI IN EXPERIMENTAL CHRONIC OBSTRUCTIVE PULMONARY DISEASES
Keywords:
bronchiectasis, experimental pneumonia, rabbits, morphologyAbstract
This article describes the methods of research of laboratory animals subjected to experimental influences. The morphofunctional features of the bronchi and lungs in experimental chronic inflammatory pathology were studied.
Research objectives. The study of morphofunctional features of the structure of the bronchi in experimental chronic obstructive pulmonary diseases.
Materials and research methods. The material for the study was the lobes and segments of the lungs of animals (32 rabbits) subjected to experimental influences. All materials were stained for hematoxylin and eosin, according to Van Gieson, resorcinol-fuchsin Weigert, and also according to Masson's method.
Research results. The dynamics of the inflammatory process was controlled and the animals were taken into experience 3, 4, and 5 months after the operation. In each group, 6-8 animals were studied. On the section in rabbits, macroscopically, lungs of a dark pink color were noted, they were enlarged, swollen, dense to the touch. Microscopically, as the duration of the experiment increased, focal hyperplasia and metaplasia of the bronchial epithelium were observed.
Conclusion. After intratracheal introduction of a thread in the lungs of rabbits, there are signs of progressive pneumonia with signs of excessive proliferation.
References
Блинова С.А., Хамидова Ф.М., Исмоилов Ж.М. Состояние иммунных и регуляторных структур слизистой оболочки бронхов при патологии лекгих у детей // Тиббиётда янги кун. Бухоро. - 2020. №2 (29). – С. 104-106. (14.00.00; №22)
Гаймоленко И.Н., Третьякова Н.Н., Тихоненко О.А., Панченко А.С. «Факторы риска и механизмы развития частой респираторной заболеваемости у детей». // Ж. Пульмонология №5. 2011. С 29-31.
Дорофиенко Н.Н. «Морфологическая характеристика слизистой оболочки бронхиального дерева у больных хроническим бронхитом» // Ж. Бюллетень физиологии и патологии дыхания. Выпуск 7. 2000., С. 55-59.
Козлов В.К., Лебедько О.А., Пичугина С.В и соавт. «Актуальные вопросы хронических неспецифических заболеваний легких у детей» // Ж. Бюллетень физиологии и патологии дыхания. Выпуск 70., 2018., С. 15-26.
Малыхин Ф.Т., Косторная И.В. «Морфологические изменения органов дыхания при хронической обструктивной болезни легких» // Ж. Архив патологии. № 1. 2016., С. 42-50.
Середа Е.В., Лукина О.Ф., Селимзянова Л.Р. «Механизмы бронхиальной обструкции и терапевтическая тактика при бронхитах у детей» // Ж. Педиатрия, 2010, том 89, №5, С.77-86.
Luke R., J.David., et.al. «Airway Mucus and Asthma: The Role of MUC5AC and MUC5B» // J.Clin.Med. 2017., 6,112: doi: 10.3390/jcm6120112.
Maksudov, D., Musurmanov, F., & Nodirhonov, S. (2021). Effectiveness of the complex treatment of odontogenic phlegmon of the maxillofacial region in patients. Збірник наукових праць SCIENTIA. вилучено із https://ojs.ukrlogos.in.ua/index.php/scientia/article/view/10529
Rui-Hong Du., Bradly Richmond. Et.al. «Saecretory IgA from submucosal gladsdoes not compensate for its airway surface deficiency in chronic obstructive pulmonary disease» // J.Virchows.Arch. 2015. December; 467(6): 657-665. Doi: 10.1007/s00428-015-1854-0.
Khamidova F.M., Blinova S.A., Ismoilov Zh.M. Morphofunctional state of immune and endocrine structures of the lungs in bronchioectatic disease in children // International Journal of Early Childhood Special Education (INT-JECS) ISSN: 1308-5581 Vol. 14. Issue 03. 2022. – Р. 10290-10294. Mukhammadieva L.A., Khamidova F.M.Diagnostic criteria for chronic lung diseases in children // International Journal of Early Childhood Special Education (INT-JECS) ISSN: 1308-5581 Vol.14. Issue 04. 2022. – Р. 1137-1147.
Rizaev J. A., Khazratov A. I., Iordanishvili A. K. Morphofunctional characteristics of the mucous membrane of the masticatory apparatus in experimental carcinogenesis //Russian Journal of Dentistry. – 2021. – Т. 25. – №. 3. – С. 225-231.
Polatova Djamila, Madaminov Ahmad, Raximov Nodir. Significance of expression of PD-L1 and p53 proteins in human papillomavirus-associated oropharyngeal squamous cellcarcinoma. Journal of Biomedicine and Practice. 2022, vol. 7, issue 4, pp. 144-151
