CARBOHYDRATE METABOLISM DISORDER IN PATIENTS WITH CUSHING SYNDROME
Keywords:
Cushing's syndrome, steroid diabetes, insulin resistanceAbstract
Impaired glucose metabolism in patients with Cushing syndrome is due to a combination of several concomitant glucocorticoid-related effects that directly or indirectly affect glucose homeostasis, mainly by inducing gluconeogenesis and impaired insulin receptor signaling. Complex interactions between genetic predisposing factors, aging, altered insulin sensitivity, and β cell function contribute to the development, progression, and HA of induced glucose metabolism abnormalities. In this regard, the purpose of this study was to study the violation of carbohydrate metabolism of patients with Cushing syndrome depending on the duration of hypercortisolemia and the activity of the disease.
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