• RUSTAMOVA Mamlakat Tulyaboevna
  • BOBOEV Kodirjon Tukhtaboyevich
  • TURSUNOVA Minavara Ulugbekovna
  • SALAEVA Muborak Saidobdullayevna
  • HALIMOVA Kholida Hakimboevna


molecular genetics, gastric and duodenal ulcer


Purpose of the study. Analysis of the role of the gene-determinant of the PGC-1A(G/A) inflammation regulator in the pathogenesis and course of gastric ulcer and duodenal ulcer.

Materials and research methods. 100 patients with gastric and duodenal ulcer were examined. Of these, groups with complications (n = 49) and without it (n = 51) were selected, which were examined for polymorphic variants of the PGC-1A(G/A) genes by PCR.

Results. The PGC-1A(G/A) are markers of the development of duodenal and gastric ulcer. Conclusion. Identification of candidate genes for peptic ulcer disease provides prevention of this pathology and plays an important role in the development of new approaches to the diagnosis and treatment of peptic ulcer disease.


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