ANTIOXIDANT THERAPY AND METOBOLIC APPROACHES TO THE TREATMENT OF CHRONIC BRUCELLOSIS.
Keywords:
Chronic brucellosis, clinic, diagnosis, antioxidant systemAbstract
Objective: To evaluate the effectiveness of phosphargine succinate in patients with chronic brucellosis.
Materials and methods: The object of the study were 85 patients aged 17 to 74 years who were treated at the Bukhara Regional Infectious Diseases Hospital.
Results and discussion: According to clinical forms, the patients were distributed as follows: primary chronic brucellosis (BCB) - 22 (25.8%) and secondary chronic brucellosis (ICB) - 63 (74.2%). Patients mainly complained of fever, weakness, headache, loss of appetite, tremor, sweating, and the like. But their meeting was different in primary and secondary chronic brucellosis. According to DAS28, it was 3.95±0.13 and 4.23±0.12 points in primary and secondary chronic brucellosis. We also evaluated LPO processes in the blood serum of patients with MDA levels. Based on the results obtained, we tried to improve the treatment of CB and for this we used the drug phosphargine succinate, produced in our republic. This drug has antihypoxant and antioxidant properties. Studies have shown it to be more effective than conventional treatment for chronic brucellosis.
Conclusions: Chronic brucellosis is characterized by an increase in the amount of MDA, a weakening of the antioxidant defense system and a decrease in the compensatory capabilities of the antioxidant system, and their changes depend on the severity of the disease. The inclusion of the drug Phosfargin in the treatment of chronic brucellosis leads to early elimination of clinical symptoms.
References
REFERENCES / СНОСКИ / ИҚТИБОСЛАР:
Avijgan M., Rostamnezhad M., Jahanbani-Ardakani H. Clinical and serological approach to patients with brucellosis: A common diagnostic dilemma and a worldwide perspective// Microbial Pathogenesis. – 2019. S125-130.
Демченко В.Г., Сафонова А.Д., Рудакова Н.В. и Ерениева С.И. Современные гигиенические, эпидемиологические и клинические аспекты бруцеллеза// Коллективная монография.- Москва: Тесса, 2014.
Kasymbekov J., Imanseitov J., Ballif J. Brucella melitensis isolates from Naryn Oblast, Kyrgyzstan // Dis.- 2013.- Vol 7. S204.
Касымов О.Ш. Ўзбекистондаги бруцеллёз ўчоқларида ажратилган қўзғотувчиларнинг микробиологик, генетик таҳлили ва касалликнинг эпидемиологик мониторингини такомиллаштириш // Автореф. дисс., -Тошкент, 2017. с. 59
Онищенко Г.Г., Куличенко А.Н. Бруцеллёз. Современное состояние проблемы // -Ставрополь: Губерния, 2019. c. 336
Расулов С.А., Мирзоев Д.М., Давлатов Х.О., Ахматбекова С.Ш. Динамика заболеваемости бруцеллёзом мелкого рогатого скота и людей в районах Республики Таджикистан с высокими показателями инфицированности// Российский ветеринарный журнал, №1. - 2016.- c. 50-54
Саркисян Н.С., Пономаренко Д.Г., Логвиненко О.В., Ракитина Е.Л., Костюченко М.В., Куличенко А.Н. Интенсивность специфической сенсибилизации и иммунный статус у больных бруцеллезом// Медицинская иммунология, №4- 2016, c. 365-372
Фарманова М.А., Касимов И.А., Атажаджаева Д.Р. Бруцеллез касаллигининг клинико-эпидемиологик хусусиятлари// Тиббиётда янги кун. 1. c. 29.
Shevtsov A., Syzdykov M., Kuznetsov A, et al. Antimicrobial susceptibility of Brucella melitensis in Kazakhstan// Antimicrob Resist Infect Control. - 2017.- Vol.6.- S.130.
Халилов Р.А., Джафарова А.М., Астаева М.Д. Оценка состояния прооксидантно-антиоксидантной системы крови и некоторых морфофункциональных параметров эритроцитов у больных хроническим бруцеллезом//The Journal of scientific articles “Health and Education Millennium”, № 9. -2016. c. 77-80.
