ASSOCIATION OF PERIODONTAL DISEASES WITH ACUTE CORONARY SYNDROME

Authors

  • RIZAEV Jasur Alimjonovich
  • AGHABABYAN Irina Rubenovna

Keywords:

periodontitis, cytokines, acute coronary syndrome

Abstract

In this review, based on numerous randomized and single-blind studies, the association of inflammatory periodontal diseases with coronary heart disease, in particular with acute coronary syndrome (ACS), was revealed. In particular, the role of pro-inflammatory cytokines - C-reactive protein, IL-6, IL-8, TNF-a in maintaining the inflammatory process in periodontitis and progression of coronary artery disease is shown. The research is noteworthy and needs to be studied more closely.

References

Nowbar AN, Howard JP, Finegold JA, Asaria P, Francis DP. Global geo graphic analysis of mortality from ischaemic heart disease by country, age and income: statistics from World Health Organisation and United Nations. Int J Cardiol. 2014;174(2):293–8.

Nazir MA. Prevalence of periodontal disease, its association with systemic diseases prevention. Int J Health Sci (Qassim). 2017;11(2):72–80.

Benjamin RM. Oral health: the silent epidemic. Public Health Rep. 2010;125(2):158–9. https://doi.org/10.1177/003335491012500202.

Oscarsson J, Johansson A. Periodontitis: from dysbiotic microbial immune response to systemic infammation. J Clin Med. 2019;8(10):1706.

Park SY, Kim SH, Kang SH, Yoon CH, Lee HJ, Yun PY, Youn TJ, Chae IH. Improved oral hygiene care attenuates the cardiovascular risk of oral health disease: a population-based study from Korea. Eur Heart J. 2019;40:1138–45.

Hujoel PP, Drangsholt M, Spiekerman C, DeRouen TA. Periodontal disease and coronary heart disease risk. JAMA. 2000;284:1406–10.

Aarabi G, Zeller T, Seedorf H, Reissmann DR, Heydecke G, Schaefer AS, Seedorf U. Genetic susceptibility contributing to periodontal and cardio vascular disease. J Dent Res. 2017;96:610–7.

Ishikawa I. Host responses in periodontal diseases: a preview. Periodontol. 2000;2007(43):9–13.

Grant MM, Jönsson D. Next generation sequencing discoveries of the nitrate-responsive oral microbiome and its efect on vascular responses. J Clin Med. 2019;8(8):1110.

Lockhart PB, Bolger AF, Papapanou PN, Osinbowale O, Trevisan M, Levison ME, Taubert KA, Newburger JW, Gornik HL, Gewitz MH, Wilson WR, Smith SC Jr, Baddour LM. American Heart Association Rheumatic Fever, Endo carditis, and Kawasaki Disease Committee of the Council on Cardiovas cular Disease in the Young, Council on Epidemiology and Prevention, Council on Peripheral Vascular Disease, and Council on Clinical Cardiol ogy. Periodontal disease and atherosclerotic vascular disease: Does the evidence support an independent association?: a scientifc statement from the American Heart Association. Circulation. 2012;125(20):2520–44.

Stary HC. Natural history and histological classifcation of atherosclerotic lesions: an update. Arterioscler Thromb Vasc Biol. 2000;20:1177–8.

Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classifca tion scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262–75.

Miśkiewicz A, Szparecki G. Periodontitis as a risk factor in cardiovascular diseases. Dent Med Probl. 2010;47(4):472–7.

Schenkein HA, Loos BG. Infammatory mechanisms linking periodontal diseases to cardiovascular diseases. J Periodontol. 2013;84(4):51–69.

Beck JD, Garcia R, Heiss G, Vokonas PS, Ofenbacher S. Periodontal disease and cardiovascular disease. J Periodontol. 1996;67:1123–37.

Thygesen K, Alpert SA, Jafe AS, Chaitman BR, Bax JJ, Morrow DA, White HD, ESC Scientifc Document Group. Fourth universal defnition of myo cardial infarction (2018). Eur Heart J. 2019;40(3):237–69.

Patel MR, Bailey SR, Bonow RO, Chambers CE, Chan PS, Dehmer GJ, Kirtane AJ, Wann LS, Ward RP. CCF/SCAI/AATS/AHA/ASE/ASNC/HFSA/ HRS/SCCM/SCCT/SCMR/STS 2012 appropriate use criteria for diag nostic catheterization: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, Society for Cardiovas cular Angiography and Interventions, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiog raphy, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society of Critical Care Medicine, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2012;59(22):1995–2027.

Neumann F-J, Sousa-Uva M, Ahlsson A, Alfonso F, Banking AP, Bened etto U, Byrne RA, Collet J-P, Falk V, Head SJ, Jüni P, Kastrati A, Koller A, Kristensen SD, Niebauer J, Richter DJ, Seferovic PM, Sibbing D, Stefanii GG, Windecker S, Yadav R, Zembala MO. 2018 ESC/EACTS Guidelines on myocardial revascularization. Eur Heart J. 2019;40:87–165.

Lang RM, Badano LP, Mor-Avi V, Aflalo J, Armstrong A, Ernande L, Flach skampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU. Recom mendations for cardiac chamber quantifcation by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardi ogr. 2015;28:1–39.

Lange DE, Plagmann HC, Eenboom A, Promesberger A. Clinical methods for the objective evaluation of oral hygiene. Deutsche Zahnärztliche Zeitschrift. 1977;32:44–7.

Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J. 1975;25(4):229–35.

Caton JG, Armitage G, Berglundh T, et al. A new classifcation scheme for periodontal and peri-implant diseases and conditions—introduc tion and key changes from the 1999 classifcation. J Clin Periodontol. 2018;45(Suppl 20):S1–8. https://doi.org/10.1111/jcpe.12935.

Calabro P, Golia E, Yeh ET. CRP and the risk of atherosclerotic events. Semin Immunopathol. 2009;31:79–94.

Paraskevas S, Huizinga JD, Loos BG. A systemic review and meta-analyses in C-reactive protein in relation to periodontitis. J Clin Periodontol. 2008;35:277–90.

Ndrepepa G, Braun S, Tada T, King L, Cassese S, Fusaro M, Keta D, Kastrati A, Schmidt R. Comparative prognostic value of C-reactive protein & fbrinogen in patients with coronary artery disease. Indian J Med Res. 2014;140:392–400. 26. Anitha G, Nagaraj M, Jayashree A. Comparative evaluation of levels of C-reactive protein and PMN in periodontitis patients related to cardiovas cular disease. J Indian Soc Periodontol. 2013;17:330–3.

Lubrano V, Balzan S. Consolidated and emerging infammatory markers in coronary artery disease. World J Exp Med. 2015;5:2–32.

Vedin O, Hagström E, Östlund O, Avezum A, Budaj A, Flather MD, Harrington RA, Koenig W, Sofer J, Siegbahn A, Steg PG, Stewart RAH, Wallentin L, White HD, Held C, On behalf of the STABILITY Investigators. Associations between tooth loss and prognostic biomarkers and the risk for cardiovascular events in patients with stable coronary heart disease. Int J Cardiol. 2017;245:271–6.

Górski B, Nargiełło E, Opolski G, Ganowicz E, Górska R. The association between dental status and systemic lipid profle and infammatory mediators in patients after myocardial infarction. Adv Clin Exp Med. 2016;25(4):625–30.

Swaroop C, Joseph K, Sankaranarayanan A, Issac A, Babu G, Wilson B, Joseph J. Evaluation of C-reactive protein and fbrinogen in patients with chronic and aggressive periodontitis: a clinico-biochemical study. JCDR. 2017;11(3):ZC41–5.

Bridge KI, Philippou H, Ariëns R. Clot properties and cardiovascular disease. Thromb Haemost. 2014;112:901–8.

Bokhari SA, Khan AA, Butt AK, Hanif M, Izhar M, Tatakis DN, Ashfaq M. Peri odontitis in coronary heart disease patients: strong association between bleeding on probing and systemic biomarkers. J Clin Periodontol. 2014;41:1048–54.

Seringec N, Guncu G, Arihan O, Avcu N, Dikmenoglu N. Investigation of hemorheological parameters in periodontal diseases. Clin Hemorheol Microcirc. 2015;61:47–58.

Gillum RF, Ingram DD, Makuc DM. White blood cell count, coronary heart disease, and death: The NHANES I Epidemiologic Follow-up Study. Am Heart J. 1993;125(3):855–63.

Danesh J, Collins R, Appleby P, Peto R. Association of fbrinogen, C-reac tive protein, albumin, or leukocyte count with coronary heart disease. JAMA. 1998;279(18):1477.

Beck JD, Heiss G, Madianos P, Couper D, Lin D, Moss K, Elter J, Ofen bacher S. Periodontal disease and coronary heart disease. Circulation. 2005;112:19–24.

Marfl-Álvarez R, Mesa F, Arrebola-Moreno A, Ramírez-Hernández JA, Magán-Fernández A, O’Valle F, Galindo-Moreno P, Catena A. Acute myo cardial infarct size is related to periodontitis extent and severity. J Dent Res. 2014;93(10):993–8.

Vedin O, Hagström E, Budaj A, Denchev S, Harrington RA, Koenig W, Sofer J, Sritara P, Stebbins A, Stewart RH, Swart HP, Viigimaa M, Vinereanu D, Wallentin L, White HD, Held C. Tooth loss is independently associated with poor outcomes in stable coronary heart disease. Eur J Prev Cardiol. 2015;8:839–46.

Rydén L, Buhlin K, Ekstrand E, de Faire U, Gustafsson A, Holmer J, Kjellström B, Lindahl B, Norhammar A, Nygren Å, Näsman P, Rathnayake N, Svenungsson E, Klinge B. Periodontitis increases the risk of a frst myocardial infarction: a report from the PAROKRANK study. Circulation. 2016;133:576–83. Wojtkowska et al. BMC Oral Health (2021) 21:5 Page 17 of 17 • fast, convenient online submission • thorough peer review by experienced researchers in your field • rapid publication on acceptance • support for research data, including large and complex data types • gold Open Access which fosters wider collaboration and increased citations • maximum visibility for your research: over 100M website views per year At BMC, research is always in progress. Learn more biomedcentral.com/submissions Ready to submit y submit your research ? Choose BMC and benefit from:

Alfredsson J, Nelly B, Nelly ML, Bhatt DL, Goldman SG, Tricoci P, Mahafey KW, Cornel JH, White HD, Fox KAA, Prabhakaran D, Winters KJ, Arm strong PW, Ohman M, Roe MT. Predicting the risk of bleeding dur ing dual antiplatelet therapy after acute coronary syndromes. Heart. 2017;103:1168–76.

Cervino G, Fiorillo L, Monte IP, De Stefano R, Laino L, Crimi S, Bianchi A, Herford AS, Biondi A, Cicciù M. Advances in antiplatelet therapy for dentofacial surgery patients: focus on past and present strategies. Materi als. 2019;2(9):1524.

Ninomiya JK, L’Italien G, Criqui MH, Whyte JL, Gamet A, Chen RS. Associa tion of the metabolic syndrome with history of myocardial infarction and stroke in the Third National Health and Nutrition Examination Survey. Circulation. 2004;109(1):42–6.

Zapolski T, Waciński P, Kondracki B, Rychta E, Buraczyńska MJ, Wysokiński A. Uric acid as a link between renal dysfunction and both pro-infamma tory and prothrombotic state in patients with metabolic syndrome and coronary artery disease. Kardiol Pol. 2011;69(4):319–26.

Tsai SJ, Lin MS, Chiu WN, Jane SW, Tu LT, Chen MY. Factors associated with having less than 20 natural teeth in rural adults: a cross-sectional study. BMC Oral Health. 2015;15:158.

Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640–5.

Folwaczny M, Wilberg S, Bumm C, Hollatz S, Oberhofer R, Neidenbach RC, Kaemmerer H, Frasheri I. Oral health in adults with congenital heart disease. J Clin Med. 2019;8(8):1255.

Sanz M, Marco Del Castillo A, Jepsen S, Gonzalez-Juanatey JR, D’Aiuto F, Bouchard P, Chapple I, Dietrich T, Gotsman I, Graziani F, Herrera D, Loos B, Madianos P, Michel JB, Perel P, Pieske B, Shapira L, Shechter M, Tonetti M, Vlachopoulos C, Wimmer G. Periodontitis and cardiovascular diseases: consensus report. J Clin Periodontol. 2020;47(3):268–88.

Li C, Lv Z, Shi Z, Zhu Y, Wu Y, Li L, Iheozor-Ejiofor Z. Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis. Cochrane Database Syst Rev. 2019;12:CD009197.

Агабабян И. Р., Исмоилова Ю. А. Эффективность амбулаторного контроля больных с хронической сердечной недостаточностью //Достижения науки и образования. – 2022. – С. 99.

Агабабян И. Р., Ярашева З. Х. Эхокардиография в прогнозировании ранней хронической сердечной недостаточности у больных пожилого возраста //Достижения науки и образования. – 2022. – С. 103.

Ризаев Ж. А. и др. Значение коморбидных состояний в развитии хронической сердечной недостаточности у больных пожилого и старческого возраста //Достижения науки и образования. – 2022. – С. 75.

Ризаев Ж. А., Хазратов А. И. Морфологические изменения слизистой полости рта при онкологических патологиях //Актуальные проблемы фундаментальной, клинической медицины и возможности дистанционного обучения. – 2020. – Т. 115.

Published

2022-09-29