CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF PROSTATE CANCER
Keywords:
prostate adenocarcinoma, clinical and morphological signs, diagnostics, research methods.Abstract
The article is devoted to the establishment of clinical and morphological features of malignant neoplasms of the prostate gland. Studies have shown that the number of cases of "hormone-resistant" prostate cancer has recently increased. In particular, the morphological diagnosis of prostate adenocarcinoma is difficult, and signs of malignancy are not always established. It was revealed that misdiagnosis occurs due to various benign processes that are similar to malignant neoplasms. Currently, immunohistological markers are widely used to identify cells in the basal layer. And with the help of immunohistochemical methods, it is possible to establish the level of these markers, which increases with prostate adenocarcinoma.
References
Bhojani N., Salomon L., Capitanio U., et al. External validation of the updated Partin tables in a cohort of French and Italian men.// Int. J. Radiat. Oncol. Biol. Phys. 2009. Vol.73 - P.347-52.
Derweesh I.H., Kupelian P.A. Continuing trends in pathological stage migration in radical prostatectomy specimens. //Urol. Oncol. – 2004. - Jul-Aug; 22(4): - P. 300-6.
Eckersberger E., Finkelstein J., Sadri H., Margreiter M., Djavan B. et al Screening for Prostate Cancer: A Review of the ERSPC and PLCO Trials. //Reviews in Urology. - Vol. 11 № 3. - 2009. – Р. 127-133
Eble J.N. et al.: Pathology and Genetics: Tumors of the urinary system and male genital organs. WHO classification of tumors. World Health Organization, Geneva, - 2004. - 299 p.
Epstein J.I., Netto G.J. Biopsy Interpretation of the Prostate. Philadelphia, JB Lippincott Williams & Wilkins, 2008. ISBN9781469887517- 440 p.
Gretzer M.B., Partin A.W. PSA markers in prostate cancer detection. //Urol. Clin. North. Am. - 30, 2003. - 30 (4): - P. 677-86. doi: 10.1016/s0094-0143(03)00057-0.
Islamov Sh.E. Subjectivity in defects in rendering medical aid // European science review, Vienna, 2018. - №11-12. – P. 95-97.
Messing E.M., Manola J., Sarosdy M. et al. Immediate hormonal therapy compared with observation after radical prostatectomy and pelvic lymphadenectomy in men with node-positive prostate cancer //N.Engl.J.Med. — 1999. — V. 341, № 9.— Р. 1781—1788.
Prayer-Galetti T., Zattoni F., Capizzi A. et al. Disease free survival in patients with pathological C stage prostate cancer at radical reropubic prostatectomy submitted to adjuvant hormonal treatment //Eur.Urol. — 2000. — V. 38. — Аbstr. 504.
Van de Kwast T. et al Single Prostatic Cancer Foci on Prostate Biopsy.// Eur Urol supp 7. 2008. – Р. 549-556.
