ASSISTED REPRODUCTIVE TECHNOLOGIES IN THE TREATMENT OF INFERTILITY IN WOMEN WITH PCOS

Authors

  • AGABABYAN Larisa Rubenovna
  • USMANKULOVA Khabiba Mizrobjonovna

Keywords:

PCOS, IVF, ART, OHSS, IUI

Abstract

The article discusses modern approaches to the diagnosis and treatment of infertility associated with PCOS in the context of ART methods. The authors analyze the effectiveness of intrauterine insemination (IUI) and in vitro fertilization (IVF), emphasizing the importance of individualized stimulation protocols. Particular attention is paid to safety issues, in particular the prevention of ovarian hyperstimulation syndrome (OHSS), and the role of metformin in preparing for ART cycles. The work is based on current recommendations from international communities (ESHRE, ASRM, NICE).

References

Azziz R. Polycystic Ovary Syndrome. Obstet Gynecol. 2018;132(2):321–336. DOI: 10.1097/AOG.0000000000002698.

Rojas J., Chávez M., Olivar L. et al. Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth. Int J Reprod Med. 2014;2014:1–17. DOI: 10.1155/2014/719050.

De Sousa S.M.C., Norman R.J. Metabolic syndrome, diet and exercise. Best Pract Res Clin Obstet Gynaecol. 2016;37:140–151. DOI: 10.1016/j.bpobgyn.2016.01.006.

Ткачук В.А., Воротников А.В. Молекулярные механизмы развития резистентности к инсулину. Сахарный диабет. 2014;17(2):29–40. DOI: 10.14341/DM2014229-40.Tkachuk V.A., Vorotnikov A.V. Molecular Mechanisms of Insulin Resistance Development. Diabetes mellitus. 2014;17(2):29–40. DOI: 10.14341/DM2014229-40.

Joham A.E., Norman R.J., Stener-Victorin E. et al. Polycystic ovary syndrome. Lancet Diabetes Endocrinol. 2022;10(9):668–680. DOI: 10.1016/S2213-8587(22)00163-2.

Unluhizarci K., Karaca Z., Kelestimur F. Role of insulin and insulin resistance in androgen excess disorders. World J Diabetes. 2021;12(5):616–629. DOI: 10.4239/wjd.v12.i5.616.

Moghetti P., Tosi F. Insulin resistance and PCOS: chicken or egg? J Endocrinol Invest. 2021;44(2):233–244. DOI: 10.1007/s40618-020-01351-0.

Kamenov Z., Gateva A. Inositols in PCOS. Molecules. 2020;25(23):5566. DOI: 10.3390/molecules25235566.

Azziz R., Carmina E., Dewailly D. et al. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril. 2009;91(2):456–488. DOI: 10.1016/j.fertnstert.2008.06.035.

Carlomagno G., Unfer V., Roseff S. The D-chiro-inositol paradox in the ovary. Fertil Steril. 2011;95(8):2515–2516. DOI: 10.1016/j.fertnstert.2011.05.027.

De Leo V., Musacchio M.C., Cappelli V. et al. Genetic, hormonal and metabolic aspects of PCOS: an update. Reprod Biol Endocrinol. 2016;14(1):38. DOI: 10.1186/s12958-016-0173-x.

Behboudi-Gandevani S., Ramezani Tehrani F., Rostami Dovom M. et al. Insulin resistance in obesity and polycystic ovary syndrome: systematic review and meta-analysis of observational studies. Gynecol Endocrinol. 2016;32(5):343–353. DOI: 10.3109/09513590.2015.1117069.

Guarano A., Capozzi A., Cristodoro M. et al. Alpha Lipoic Acid Efficacy in PCOS Treatment: What Is the Truth? Nutrients. 2023;15(14):3209. DOI: 10.3390/nu15143209.

Tosi F., Bonora E., Moghetti P. Insulin resistance in a large cohort of women with polycystic ovary syndrome: a comparison between euglycaemic-hyperinsulinaemic clamp and surrogate indexes. Hum Reprod. 2017;32(12):2515–2521. DOI: 10.1093/humrep/dex308.

Cassar S., Misso M.L., Hopkins W.G. et al. Insulin resistance in polycystic ovary syndrome: a systematic review and meta-analysis of euglycaemic-hyperinsulinaemic clamp studies. Hum Reprod. 2016;31(11):2619–2631. DOI: 10.1093/humrep/dew243. Shakhanova S. et al. MELANOMA OF THE SKIN AND PREGNANCY //Eurasian Journal of Academic Research. – 2023. – T. 3. – No. 3. – pp. 120-128.

Abdurakhmonov Jurabek , Rahimov Nodir , Shakhanova Shakhnoza . Modern view on ascite in ovarian cancer. Journal of Biomedicine and Practice . 2022, vol . 7, issue 4, pp . 130-139

Jasur Rizayev Alimjanovich , Larisa Rubenovna Agababyan , Anvar Ibragimovich Kamalov . AYOLLARDA TUG'RUQDAN KEYINGI QON KETISHLARNI OLDINI OLISH VA ULARGA QARSHI KURASHISH BO'YICHA KO'RSATILAYOTGAN XIZMATLAR SIFATINING MONITORINGINI TASHKIL ETISH // Oriental Renaissance: Innovative, educational, natural and social sciences Volume 1_ ISSUE 10 202 1 p.m. 166-169

Alimjanovich JR, Agababyan LR, Kamalov AI Prevention and Treatment of Postpartum Hemorrhage //CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES. – 2021. – T. 2. – No. 4. – S. 204-209.

Rizaev Jasur Alimjanovich , Agababyan Larisa Rubenovna , Davlatova Aziza, Ahmedova Aziza Tayirovna , Rasulova Feruza Golibovna , The state of the oral cavity in pre-pregnant women, Journal of reproductive health and uronephrology research 2023, vol. 4, issue 4, pp7-11

Rizaev J. A., Nazarova N. S., Vohidov E. R. HOMILADOR AYOLLARDA PARODONT KASALLIKLARI RIVOJLANISHINING PATOGENETIK JIHATLARI //Журнал гуманитарных и естественных наук. – 2024. – №. 11 [2]. – С. 104-107.

Published

2026-05-06