ASSESSMENT OF THE IMMUN SYSTEM STATUS IN ACUTE DESTRUCTIVE PANCREATITIS
Keywords:
acute pancreatitis, immunodeficiency, hard courseAbstract
To assess the degree of immunodeficiency in acute destructive pancreatitis.This study is based on the results of a prospective examination of 97 patients with acute pancreatitis who were treated in the surgical departments of the Samarkand branch of republican research center of emergency medicine from 2020 to 2025. The diagnostic and therapeutic procedures were carried out in accordance with the protocols for the diagnosis and treatment of acute pancreatitis. In the destructive form of acute pancreatitis, the absolute number of T-lymphocytes decreased from 0.97±0.03 to 0.43±0.06 g/l, and in percentage terms - from 55.9% to 50.9%. This indicates a pronounced immunodeficiency due to a reduction in T-helpers. The slight decrease in T-suppressors was not statistically significant. The number of NK cells remained within normal limits. The immunoregulatory index (IRI) decreased significantly, indicating marked cellular immunodeficiency. No statistically significant changes were observed in the phagocytic component. Circulating immune complexes (CIC) were slightly reduced at the time of examination. The nature and degree of immunodeficiency are directly related to the severity of the disease. It should be noted that there is a correlation between the level of immunodeficiency and the volume of pancreatic necrosis. As evidence of this relationship, the simultaneous manifestation of two processes - the formation of pancreatic necrosis foci and the appearance of signs of immunodeficiency was observed within the first 48 hours after the onset of acute pancreatitis.
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