SIGNIFICANCE OF IL10 RS1800872, SERPINE1 RS1799768, NOS3 RS2070744, AND IL1Β RS1143627 GENE POLYMORPHISMS IN PURULENT-NECROTIC PROCESSES OF THE MAXILLOFACIAL REGION
Keywords:
purulent-necrotic processes of the maxillofacial region, gene polymorphism, IL10, SERPINE1, molecular geneticsAbstract
This study is devoted to determining the pathogenetic significance of IL10 rs1800872, SERPINE1 rs1799768, NOS3 rs2070744, and IL1β rs1143627 gene polymorphisms in purulent-necrotic processes of the maxillofacial region developing under the influence of various etiological factors. The results of molecular genetic analyses demonstrated that these genes play an important role in the regulation of inflammatory processes, disturbances of microcirculation, the formation of thrombogenic states, and alterations of the immune response. Polymorphisms of the IL10 gene affect the efficiency of anti-inflammatory mechanisms, potentially contributing to a more severe course of necrotic processes. Variants of the SERPINE1 and NOS3 genes are associated with endothelial dysfunction and impaired tissue perfusion. Polymorphisms of the IL1β gene are characterized by excessive activation of inflammatory mediators. The obtained results indicate the promising potential of these genetic markers for early diagnosis of purulent-necrotic lesions of the maxillofacial region, identification of high-risk groups, and development of individualized therapeutic strategies.
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