GENETIC FACTORS OF ACNE
Keywords:
Acne, molecular genetic mechanisms, kelliod, prognosisAbstract
Purpose of the study. Conducting a literature analysis of genetic predisposition and risk factors for acne.
Research results. Understanding of the molecular and genetic mechanisms underlying acne and acne scar formation is still in its infancy. However, ongoing research in this area increases our knowledge of disease mechanisms and may contribute to the development of new preventive and treatment strategies. Research confirms the significant role of genetic factors in the development of acne, affecting its occurrence, course and effectiveness of treatment. Particular attention is paid to gene polymorphisms associated with inflammation, androgen metabolism and the immune response, such as CYP17A1 and TNF-α. These data highlight the importance of taking patients' genetic profile into account when diagnosing and choosing therapy, which can improve treatment outcomes and prevent disease relapse. Based on an analysis of literature data, in Uzbekistan there is insufficient understanding of the prognostic significance and role of the NLR and TLR2 genes in the development of acne. This highlights the complexity of the genetic component of acne and indicates the need for additional research to better understand the influence of these and other genetic factors on the pathogenesis of the disease.
Conclusion. An in-depth study of the genetic aspects of acne will not only enrich the scientific understanding of the disease, but will also open up new opportunities for its more effective treatment and prevention.
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Статья поступила в редакцию 20.07.2024; одобрена после рецензирования 21.08.2024; принята к публикации 24.08.2024.
The article was submitted 20.07.2024; approved after reviewing 21.08.2024; accepted for publication 24.08.2024.
Информация об авторах:
Хамидова Фарида Муиновна - д.м.н., доцент. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. Е-mail: xamidova.m.05@mail.ru, https://orcid.org/0000-0001-6084-7025
ХУСИНОВА Фируза Азгар кизи - Врач-косметолог. Самарканд. Клиника «Ориё эстет». Е-mail: Firuza_h_a@mail.ru, https://orcid.org/ 0009-0001-7935-8958
Information about the authors:
Khamidova Farida Muinovna - candidate of medical sciences, associate professor. Samarkand State Medical University, Samarkand, Uzbekistan. E-mail: xamidova.m.05@mail.ru, https://orcid.org/0000-0001-6084-7025
Khusinova Firuza Azgar kizi - Cosmetologist -Samarkand, Uzbekistan. E-mail: Firuza_h_a@mail.ru, https://orcid.org/ 0009-0001-7935-8958
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Хамидова Ф.М. — идеологическая концепция работы, написание текста; редактирование статьи;
ХУСИНОВА Ф. А.- сбор и анализ источников литературы, написание текста.
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the authors:
Khamidova FM- ideological concept of the work, writing the text; editing the article;
Khusinova F. A.- collection and analysis of literature sources, writing the text.
