GENETIC ASPECTS OF NEWBORN RESPIRATORY DISTRESS SYNDROME
Keywords:
RDS, newborns, genetic mutations, prognosisAbstract
Purpose of the study. Conducting a literature analysis of genetic predisposition and risk factors for neonatal respiratory distress syndrome.
Research results. Respiratory distress syndrome (RDS) is a respiratory disorder in newborns that occurs immediately after birth. It is one of the most common causes of neonatal intensive care unit admission and respiratory failure in newborns. RDS, caused by a lack of surfactant in the lungs, is more common in premature infants but can also occur in full-term infants. Genetic factors play a significant role in susceptibility to RDS. Electron microscopy and genetic testing, including sequencing of the SFTPB, SFTPC, and ABCA3 genes, can be useful in diagnosing and understanding the molecular mechanisms of RDS. To improve respiratory outcomes in newborns with RDS, it is important to take into account genetic factors, which will allow timely and adequate implementation of preventive and therapeutic measures. The prognosis for RDS depends on the severity and underlying cause of the disease.
Conclusion. RDS is a serious condition that requires immediate medical attention. Understanding risk factors and regional differences in disease prevalence can help develop effective prevention and treatment strategies.
References
Horowitz K, Feldman D, Stuart B, Borgida A, Ming Victor, Fang Y, Herson V. // Full-term neonatal intenstive care unit admission in an urban community hospital: the role of respiratory morbidity. The Journal of Maternal-Fetal & Neonatal Medicine. 2011;24(11):1407–1410.
Gallacher D, Hart K, Kotecha S. // Common respiratory conditions of the newborn. Breathe. 2016;12(1):30–42.
Chalacon M, Debillon T, Plantaz D, Ego A. // Facteurs de risque de détresse respiratoire chez les prématurés modérés (32 à 34 semaines d’aménorrhée) [Internet] Médecine humaine et pathologie. 2012. Available from:
Shaili Amatya1, Meixia Ye, Lili Yang, Chintan K. Gandhi, Rongling Wu, Beth Nagourney and Joanna Floros. // Single Nucleotide Polymorphisms Interactions of the Surfactant Protein Genes Associated With Respiratory Distress Syndrome Susceptibility in Preterm Infants. // ORIGINAL RESEARCH published: 04 October 2021 Frontiers in Pediatrics
Qian L, Liu C, Guo Y, et al. // Current status of neonatal acute respiratory disorders: a one-year prospective survey from a Chinese neonatal network. Chin Med J (Engl) 2010;123:2769–2775
Jian Wang, Xuehua Liu, Tong Zhu, Chaoying Yan. // Analysis of neonatal respiratory distress syndrome among different gestational segments. Int J Clin Exp Med. 2015;8(9):16273–16279
Bouziri A, Ben Slima S, Hamdi A, et al. // Acute respiratory distress syndrome in infants at term and near term about 23 cases. Tunis Med. 2007;85:874–879.
Nagendra, K., Wilsom, C.G., Ravichander, B., Sood, S., Singh, S.P. (2017).
Ghafoor T, Mahmud S, Ali S, Dogar SA. // Incidence of respiratory distress syndrome. Journal of the College of Physicians and Surgeons, Pakistan : JCPSP. 2003;13(5):271–273
Bakr A, Abbas M. // Severe respiratory distress in term infants born electively at high altitude. BMC Pregnancy and Childbirth. 2006;6 (1).
Reuter S, Moser C, Baack M. // Respiratory Distress in the Newborn. Pediatrics in Review. 2014;35(417)/
Hansen, A.K., Wisborg, K., Uldbjerg, N., Henriksen, T.B. (2008).
Jing Liu, Na Yang, Ying Liu. // High-risk Factors of Respiratory Distress Syndrome in Term Neonates: A Retrospective Case-control Study. Balkan Med J. 2014;31(1):64–68.
Anatolyevna B. S., Muinovna K. F. Morphofunctional relationships of cells in the bronch in chronic inflammation //The American Journal of Medical Sciences and Pharmaceutical Research. – 2023. – Т. 5. – №. 06. – С. 100-104.
Авагимян А. А. и др. Сравнительная характеристика кардиопротекторных эффектов дапаглифлозина и триметазидина на модели доксорубицин-циклофосфамидной кардиотоксичности //Инновационная медицина Кубани. – 2023. – №. 4. – С. 6-14.
MUINOVNA K. F. et al. THE IMPORTANCE OF MARKERS CK7 AND TTF-1 IN METASTATIC LUNG TUMORS //JOURNAL OF BIOMEDICINE AND PRACTICE. – 2023. – Т. 8. – №. 3.
Kumar A, Bhat BV. // Epidemiology of respiratory distress of newborns. Indian journal of pediatrics. 1996;63(1):93–98.
Fedakar A, Aydogdu C. // Clinical features of neonates treated in the intensive care unit for respiratory distress. The Turkish journal of pediatrics. 2011;53(2):173–179
Abdelrahman SM, Hamed SM, Nasr A. // Neonatal respiratory distress in Omdurman Maternity Hospital, Sudan. Sudanese journal of paediatrics. 2014;14(1):65–70
Rubaltelli FF, Dani C, Reali MF, et al. // Italian Group of Neonatal Pneumology. Acta paediatrica. 12. Vol. 87. Oslo, Norway: 1992. Acute neonatal respiratory distress in Italy: a one-year prospective study; pp. 1261–1268. 1998
Mikko Hallman, Ritva Haataja. // Frontiers in Bioscience 12, 2670-2682, January 1, 2007] 2670 Genetic basis of respiratory distress syndrome
Gao Y, Li J. //Significance of combined application of biomarkers in the diagnosis and prognosis assessment of patients with acute respiratory distress syndrome. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2021 Jan;33(1):69-73. Chinese.
Д.Ю. Овсянников, Е.В. Бойцова, М.А. Жесткова, И.В. Кршеминская, И.К. Ашерова, С.Е. Украинцев, С.С. Межинский. НЕОНАТАЛЬНАЯ ПУЛЬМОНОЛОГИЯ. Монография Под редакцией Д.Ю. Овсянникова Москва 2022 СТР.168
Hamidova F. Methodology of Organizing the Stage of Training Lexical Units //Journal of Language Pedagogy and Innovative Applied Linguistics. – 2024. – Т. 2. – №. 3. – С. 11-15.
Исмоилов Ж. М. и др. СТРУКТУРНОЕ КОМПОНЕНТЫ СТЕНКИ БРОНХИАЛЬНОГО ДЕРЕВО И ИХ ГИСТОГЕНЕЗ И ВОЗРАСТНЫЕ ИЗМЕНЕНИЕ (обзор литературы) //Научный Фокус. – 2024. – Т. 1. – №. 12. – С. 460-471.
Muinovna X. F. et al. CHARACTERISTICS OF CHANGES IN THE NERVOVASCULAR SYSTEM IN THE NECK REGION DURING HANGING ON THE STRANGULATION LOOP (LITERATURE REVIEW) //Научный Фокус. – 2024. – Т. 1. – №. 11. – С. 478-484.
Журавлева Л.Н., Новикова В.И. // Определение концентрации сурфактантного белка d в сыворотке крови и трахеобронхиальном секрете при респираторном дистресс-синдроме и врожденной пневмонии у недоношенных новорожденных // Вестник ВГМУ. 2019.
Овсянников Д.Ю., Жесткова М.А., Стрельникова В.А., Аверин А.П и др. ГЕНЕТИЧЕСКИЕ ДИСФУНКЦИИ СИСТЕМЫ СУРФАКТАНТА У ДЕТЕЙ: РЕЗУЛЬТАТЫ МНОГОЦЕНТРОВОГО ИССЛЕДОВАНИЯ // Доктор.Ру. 2023. №3.
Муиновнa Х. Ф. и др. PОЛЬ ПЛAЦЕНТЦИТА В ВОЗНИКНОВЕНИЕ ВPОЖДЕННОЙ ПНЕВМОНИИ У НЕДОНОШЕННЫХ НОВОPОЖДЕННЫХ //IMRAS. – 2024. – Т. 7. – №. 1. – С. 486-492.
Muinovna K. F., Mardonovich I. J. Nonspecific and specific factors of bronchopulmonary tissue in inflammatory pathology //Journal Of Biomedicine And Practice. – 2023. – Т. 8. – №. 2.
Rizaev JA, Khazratov AI, Iordanishvili AK Morphofunctional characteristics of the mucous membrane of the masticatory apparatus in experimental carcinogenesis //Russian Journal of Dentistry. – 2021. – T. 25. – No. 3. – pp. 225-231.
Статья поступила в редакцию 11.07.2024; одобрена после рецензирования 21.08.2024; принята к публикации 24.08.2024.
The article was submitted 11.07.2024; approved after reviewing 21.08.2024; accepted for publication 24.08.2024.
Информация об авторах:
Хамидова Фарида Муиновна - д.м.н., доцент. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. Е-mail: xamidova.m.05@mail.ru, https://orcid.org/0000-0001-6084-7025
Рузикулов Собир Жовлиевич - врач- патологоанатом. Сурхандарьинское патологоанатомическое бюро. Термиз, Узбекистан. Е-mail: sobirru764@gmail.com, https://orcid.org/ 0009-0001-7935-8958
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Хамидова Ф.М. — идеологическая концепция работы, написание текста; редактирование статьи;
Рузикулов С. Ж.- сбор и анализ источников литературы, написание текста.
Information about the authors:
Khamidova Farida Muinovna - candidate of medical sciences, associate professor. Samarkand State Medical University, Samarkand, Uzbekistan. E-mail: xamidova.m.05@mail.ru, https://orcid.org/0000-0001-6084-7025
Ruzikulov Sobir Zhovlievich - pathologist. Surkhandarya pathological bureau. Termiz, Uzbekistan. E-mail: sobirru764@gmail.com https://orcid.org/ 0009-0001-7935-8958
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the authors:
Khamidova FM- ideological concept of the work, writing the text; editing the article;
Ruzikulov S. Zh.- collection and analysis of literature sources, writing the text.
