THE ROLE OF BLOOD COAGULATION INDICATORS IN CORONAVIRUS INFECTION DISEASE
Keywords:
COVID-19, coagulopathy, anticoagulants, D-dimer, prothrombin time, fibrinogenAbstract
To determine the prognosis and outcome of coronavirus infection, the main point is pathogenetic therapy aimed at correcting hemostasis disorders. Coagulation system indicators play an important diagnostic role. The review analyzes clinical research data proving the diagnostic value of D-dimers, fibrinogen, prothrombin time and platelet count to identify hemostasis disorders and assess the severity of the inflammatory response.
References
Karamatullaeva, Z. E., Orzikulov, A. O., & Ibragimova, E. F. The Importance of Anticoagulants in the Treatment of COVID-19. Journal of Hepatogastroenterological Research. Quarterly Scientific and Practical Journal. 2021; 1, 107-110. (in Russ).
Karamatullaeva Z. E., Ibragimova E. F., Mustaeva G. B. The role of microelements in COVID-19 disease. International Scientific and Practical conference «COVID-19 and other topical infections of Central Asia». 2022. 116. (in Russ).
Karamatullayeva Z.E., Ibragimova E.F. Changes in the blood coagulation system in COVID-19 disease. IQRO. 2023; 2, 137-139. (in Uzb).
Orzikulov, A. O., Rustamova, Sh. A., Karamatullaeva, Z. E., & Ibragimova, E. F. The role and significance of anticoagulants in the treatment of COVID-19 infection. 2022; 333. (in Uzb).
Rustamova Sh. A., Mirzaeva D. A. Early clinical and epidemiological diagnostics of coronavirus infection in the elderly. Collection of materials of the international online scientific and practical conference. Actual problems of environmental protection and public health during the coronavirus infection pandemic (COVID-19). 2020; 94-98. (in Uzb).
Rustamova Sh. A., Mirzaeva D. A. Modern approaches to diagnostics, prevention, treatment and rehabilitation of COVID-19. Collection of materials of the III International Congress: Continuous medical education in the Republic of Kazakhstan. 2020. (in Russ).
Rabimkulovna S. G., Farmanovna I. E., Rajabboyevna A. R. Functional disorders in patients with uncontrolled bronchial asthma. JournalNX. 2021; 7(02):199-201.
Orzikulov A.O., Rustamova Sh.A., Karamatullaeva Z.E., Ibragimova E.F. The role and importance of anticoagulants in the treatment of COVID-19 infection. Proceedings of the international scientific and practical conference with the participation of international partner universities: Achievements of modern medicine in the study of the epidemiology of infectious diseases. 2021; 206-215. (in Uzb).
Orzikulov A.O., Rustamova Sh.A., Karamatullaeva Z.E., Ibragimova E.F. The importance of D-dimer in the development of thromboembolic complications in COVID-19. Problems of biology and medicine. 2021; 6 (132), 240-246. (in Uzb).
Samibaeva U. Kh., Oslanov A. A., Karamatullaeva Z. E., Ochilov O., Khodzhieva Sevginoz Diagnostic importance of computed tomography in the diagnosis of the disease of Covid-19. Journal of Biomedicine and Practice. 2022; 7(3). (in Uzb).
Shodieva G.R., Rustamova Sh.A., Karamatullaeva Z.E. Significance of ultrasound elastometry in assessing the degree of fibrosis in chronic liver diseases. Problems of biology and medicine. 2022; 3(136), 128-132. (in Uzb).
Shodieva G.R., Rustamova Sh.A. Clinico-laboratory characteristics of liver cirrhosis with viral etiology. Bulletin of the Tashkent Medical Academy. Special issue dedicated to the international scientific and practical conference. 150-154. (in Uzb).
Shodieva G.R. The Role of Cytokines in Patients with Liver Cirrhosis of Viral Etiology. Bulletin of Science and Education. 2020; 4 (88), 104-106. (in Russ).
Shodiyeva G.R., Rustamova S.A., Ibragimova E.F. Correlation between respiratory system obstruction and changes in the cardiovascular system in bronchial asthma. Oriental renaissance: Innovative, educational, natural and social sciences. 2021; 1(11), 1214-1218. (in Uzb).
Billett H.H., Reyes-Gil M., Szymanski J., Ikemura K., Stahl L.R., Lo Y., et al. Anticoagulation in COVID-19: Effect of Enoxaparin, Heparin, and Apixaban on Mortality. Thromb Haemost 2020; 120: 1691–9. 41.
Gupta N., Zhao Y.-Y., Evans C. E. The stimulation of thrombosis by hypoxia. Thromb Res 2019; 181: 77–83.
Hajibeygi , R., Mirghazanfari , S. M., Pahlavani , N., Jalil, A. T., Alshahrani , S. H., Rizaev , J. A., ... & Yekta , N. H. (2022). Effect of a diet based on Iranian traditional medicine on inflammatory markers and clinical outcomes in COVID-19 patients: A double-blind, randomized, controlled trial. European Journal of Integrative Medicine, 102179.
Zeynitdinova , Z. A. , RIZAEV , J. A. , & Oripov , F. WITH . (2022). The degree of cytological damage to the epithelium of the buccal mucosa in COVID-19. JOURNAL OF BIOMEDICINE AND PRACTICE, 7(2).
Umirzakov Zokir , Rizaev Jasur , UMIROV Safar . The phenomenon of the epidemic
covid-19 process and their leading determinants. Journal of Biomedicine and Practice. 2021, vol . 6, issue 6, pp . 286-295
Статья поступила в редакцию 09.07.2024; одобрена после рецензирования 21.08.2024; принята к публикации 24.08.2024.
The article was submitted 09.07.2024; approved after reviewing 21.08.2024; accepted for publication 24.08.2024.
Информация об авторах:
Караматуллаева Зебо Эркиновна- ассистент. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. E-mail karamatullaevazebo@gmail.com https://orsid.org/0009-0001-5932-5091
Ибрагимова Эльнара Фармановна - cтарший преподаватель. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. Е-mail elnara-2028@mail.ru https://orcid.org/0000-0002-9929-1615
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Караматуллаева З.Э. - идеологическая концепция работы, редактирование статьи;
Ибрагимова Э.Ф. — сбор и анализ источников литературы, написание текста.
Information about the authors:
Karamatullaeva Z.E. — assistant. Samarkand state medical university. Samarkand, Uzbekistan; E-mail: karamatullaevazebo@gmail.com https://orsid.org/0009-0001-5932-5091
Ibragimova E.F. — Senior Lecturer. Samarkand state medical university. Samarkand, Uzbekistan; E-mail: stomatologiya@mail.ru, https://orcid.org/0000-0051-5463-940X
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the authors:
Кaramatullayeva Z.Е.— ideological concept of the work, writing the text; editing the article;
Ibragimova E.F. — collection and analysis of literature sources, writing the text.
