RISK OF DEVELOPING CHRONIC KIDNEY DISEASE WITH OBESITY AND A MODERN APPROACH TO DIAGNOSIS
Keywords:
body mass index, obesity, chronic kidney disease, microalbuminuria, glomerular filtration rateAbstract
Obesity is one of actual medico-social problems of modern society. Rapid growth of the persons suffering from excess mass of a body, defines relevance of this problem. Obesity leads to progressive injury of kidneys through a set of mechanisms. Use of early biomarkers of pathology of kidneys at obesity with an assessment of level of indicator of microalbuminuria is perspective for diagnostics of renal defeat at obesity. The purpose of this study is to study the level of impaired renal function with obesity, and to identify its significance as a risk factor in the development of CKD
References
Vyalkova A.A., Lebedeva E.N., Clinical and pathogenetic aspects of kidney damage in obesity (literature review) Nephrology. 2014;18(3):24-33 (In Russ)
Saginova E.A., Fomin V.V., Moiseev S.V., Lebedeva M.V. Kidney damage in obesity.// Ter arkh 2007;(5):88-94 (In Russ)
Assady S, Wanner N, Skorecki KL & Huber TB New insights into podocyte biology in glomerular health and disease. J. Am. Soc. Nephrol 2017; 28: 1707–1715.
Boger, CA, & Heid, IM. Chronic kidney disease: novel insights from genome-wide association studies. Kidney and Blood Pressure Research, 2011; 34: 225–234.
Sigitova ON, Bikmukhammetova ZheI, Nadeeva RA. Microalbuminemia - diagnostic and prognostic value for arterial hypertension. //Art Hypertension 2009;15(6):627-632 (In Russ)
Wolf G. Obesity and Renal Disease: Introduction. //Semin Nephrol. 2013 Jan; 33(1):1.
Wickman C, Kramer H. Obesity and kidney disease: potential mechanisms. //Semin Nephrol. 2013 Jan; 33(1):14-22.
Статья поступила в редакцию 07.07.2024; одобрена после рецензирования 21.08.2024; принята к публикации 24.08.2024.
The article was submitted 07.07.2024; approved after reviewing 21.08.2024; accepted for publication 24.08.2024.
Сведения об авторах:
Ахмедова Нилуфар Шариповна, Д.м.н., доцент кафедры «Гематологии и клинической лабораторной диагностики» Бухарского государственного медицинского факультета, +998 91 409 78 27, https://orcid.org/0009-0002-3864-3987
Махмудов Равшан Барраевич, ассистент кафедры «Факультетской и госпитальной терапии» Бухарского государственного медицинского института ravshan.maxmudov.85@mail.ru +998936866026 https://orcid.org/0009-0004-9626-3100
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикatsiей настоящей статьи.
Вклад авторов:
Ахмедова Н.Ш. — идеологическая концепция работы, редактирование статьи;
Махмудов Р.Б. — сбор и анализ источников литературы, написание текста.
Information about authors:
Akhmedova Nilufar Sharipovna, Doctor of Medical Sciences, Associate Professor of the Department of Hematology and Clinical Laboratory Diagnostics, Bukhara State Medical Faculty, +998 91 409 78 27, https://orcid.org/0009-0002-3864-3982
Makhmudov Ravshan Barraevich, assistant at the Department of Faculty and Hospital Therapy, Bukhara State Medical Institute ravshan.maxmudov.85@mail.ru +998936866026 https://orcid.org/0009-0004-9626-3100
Sources of funding: The work did not have special funding.
Conflict of interest: The authors declare that there are no obvious or potential conflicts of interest related to the publication of this article.
Authors' contributions:
Akhmedova N.Sh. — ideological concept of the work, article editing;
Makhmudov R.B. — collection and analysis of literature sources, writing text.