FACTORS ASSOCIATED WITH SYSTOLIC DYSFUNCTION OF THE RIGHT VENTRICLE IN PATIENTS WITH A HISTORY OF MYOCARDIAL INFARCTION
Keywords:
Right ventricular dysfunction; ischemic heart disease; myocardial infarctionAbstract
The article describes a study that analyzed the features of right ventricular involvement in patients who had suffered a myocardial infarction (MI), taking into account the assessment of global contractility of both the left and right ventricles. The examination of MI patients included biomarker analysis and echocardiography (EchoCG). The aim of the study was to analyze the factors influencing the development of right ventricular dysfunction in MI patients with impaired left ventricular contractile function. A total of 144 patients with previous myocardial infarctions of different localizations and decreased left ventricular ejection fraction underwent examination. Patients were divided into two groups: the first group (n=42) with right ventricular involvement, and the second group (n=102) without right ventricular involvement in the pathological process. According to the study findings, the frequency of right ventricular systolic dysfunction among patients with a history of myocardial infarction was 29.2%. Patients with right ventricular dysfunction were more prone to higher (III–IV) functional classes of chronic heart failure according to the New York Heart Association classification [17] (66.7% vs. 19.6%, p<0.001). Right ventricular dilation was more frequently detected in the first group (71% vs. 27%, p<0.005). Echocardiography in patients with right ventricular dysfunction showed higher values of left ventricular end-diastolic volume (195.0±31.1 vs. 118.67±24.68 ml, p<0.005), systolic pulmonary artery pressure (31.76±12.7 vs. 22.33±5.4 mmHg, p<0.005), and more frequent left ventricular contractile function reduction (left ventricular ejection fraction 43.58±4.93% vs. 53.87±6.29%, p<0.001). Correlation analysis results showed an association between right ventricular dysfunction and left ventricular functional status. Thus, a decrease in right ventricular contractile capacity was detected in 29.2% of patients with ischemic heart disease who had suffered a myocardial infarction. Right ventricular systolic dysfunction was associated with decreased left ventricular ejection fraction, increased systolic pulmonary artery pressure, and functional class of heart failure.
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Статья поступила в редакцию 02.07.2024; одобрена после рецензирования 20.08.2024; принята к публикации 24.08.2024.
The article was submitted 02.07.2024; approved after reviewing 20.08.2024; accepted for publication 24.08.2024.
Информация об авторах:
Ташкенбаева Элеонора Негматовна - д.м.н., профессор, заведующая кафедрой внутренних болезней и кардиологии №2. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. Е-mail: Eleonora_88@mail.ru, https://orcid.org/0000-0002-9942-2910
Рахманов Баходир Халикович - заведующий отделением ультразвуковой диагностики, клиника Neyro Vertebro Servis, Навои, Узбекистан. Е-mail: b.rakhmanov.uzb@gmail.com, https://orcid.org/0009-0007-9100-1525
Холиков Ихтиёр Баходирович – базовый докторант кафедры внутренних болезней и кардиологии №2. Самаркандский государственный медицинский университет, Самарканд, Узбекистан. Е-mail: ikhtiyorkhalikov.cardiologist@gmail.com, https://orcid.org/0009-0006-9466-2436
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Ташкенбаева Э.Н. — идеологическая концепция работы, редактирование статьи;
Рахманов Б.Х. — идеологическая концепция работы, написание текста.
Холиков И.Б. — сбор и анализ источников литературы, написание текста.
Information about the authors:
Eleonora N. Tashkenbaeva — DSc, professor, the head of the Department of Internal Medicine and Cardiology No.2. Samarkand state medical university. Samarkand, Uzbekistan; E-mail: Eleonora_88@mail.ru, https://orcid.org/0000-0002-9942-2910
Bakhodir Kh. Rakhmanov — Head of Ultrasound Diagnostics Department, Neyro Vertebro Servis Clinic. Navoi, Uzbekistan; E-mail: b.rakhmanov.uzb@gmail.com, https://orcid.org/0009-0007-9100-1525
Ikhtiyor B. Kholikov — PhD student at the Department of Internal Medicine and Cardiology No.2. Samarkand state medical university. Samarkand, Uzbekistan; E-mail: ikhtiyorkhalikov.cardiologist@gmail.com, https://orcid.org/0009-0006-9466-2436
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the authors:
Tashkenbaeva E.N. — ideological concept of the work, editing the article;
Rakhmanov B.Kh. — ideological concept of the work; writing the text.
Kholikov I.B. — collection and analysis of literature sources; writing the text.
